In‐situ Glycine Sensor Development Based ZnO/Al₂O₃/Cr₂O₃ Nanoparticles

Abstract

Initially, low‐dimensional ternary nanoparticles of ZnO/Al2O3/Cr2O3 were synthesized using reliable solvothermal process and successfully implemented to fabricate enzyme‐less selective glycine (Gly) sensor. The calibration curve was plotted from the linear relation of current versus concentration of glycine. By using the slope of resultant calibration curve, the sensitivity (2.09*102 μAμM−1cm−2) of Gly sensor was estimated by considering the active surface area of fabricated sensor probe. The proposed enzyme‐free Gly biosensor was found linear over large concentration range of 0.1 nM ∼ 1.0 μM, known as linear dynamic range (LDR). The detection limit (82.25±4.11 pM) was calculated at signal to noise ratio of 3 from the calibration curve. The proposed enzyme‐less Gly sensor was exhibited good reproducibility, long‐term stability and efficiency to detect Gly in real biological samples by electrochemical approach. Thus, this novel research methodology might be a good technique for the development of enzyme‐less sensor using ternary metal oxide nanoparticles onto GCE for the biomedical applications.

An Electrochemical Approach for the Selective Detection of Cancer Metabolic Creatine Biomarker with Porous Nano-Formulated CMNO Materials Decorated Glassy Carbon Electrode

“…A comparison between similar research is represented in Table 1 , in terms of sensitivity, linear dynamic range and detection limit [ 64 , 65 ]. It observes that the fabricated sensor probe is selective towards target CA in enzyme-less sensing with low-dimensional nano-formulated ternary CMNO NMs by using electrochemical methods, which related other reports in enzyme-less CA detection with different sensing matrixes such as nanomaterials or nanocomposites [ 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 ].…”

Assessment of Melamine in Different Water Samples with ZnO‐doped Co3O4Nanoparticles on a Glassy Carbon Electrode by Differential Pulse Voltammetry

“…ZnO is widely used semi‐conductor and fascinated to researchers due to its promising electrochemical properties, non‐toxic in nature, good stability with amazing photo‐sensitivity, excellent electron communication capacity. As a result, it is found as sensing elements to the fabrication of Glycine, [23] L‐glutamic acid, [24] and D‐fructose [25] sensors applying electrochemical (I−V) approach. Besides this, cobalt oxides is a typical semi‐conductive (p‐type) metal oxides with attractive characteristics such as excellent electrochemical properties, high‐surface‐to‐volume ratio, environmental‐friendly with photo‐degradable nature and having optical band‐gap of 1.76∼3.15 eV, which are favorable to the electrochemical application for the development of the sensor.…”

An Alternative Electrochemical Approach to Detect 4-Nitrophenylhydrazine With ZnO/SnO2 Nanoparticles Decorated Glassy Carbon Electrode

“…The XPS spectral peak showing the high intensity located at 530.8 eV in Fig. 1(b) is identi ed of O1s and identi ed to lattice oxygen of ionization state of O2-in the prepared ZnO/SnO2 NPs [38][39][40]. Besides this, the Sn3d level orbital in Fig.…”