In situ generation of ruthenium-chiral phosphine complexes and their use in asymmetric hydrogenation

Synthesis and structures of two ruthenium dibenzoylmethane triphenylphosphine mixed ligand complexes

“…Some of them reveal good catalytic effects [7,8] and remarkable biological activities [9,10]. However, in spite of extensive work, only a few fully structurally characterized ruthenium b-diketonate complexes containing phosphines have been published, so far [11][12][13][14][15].…”

Ruthenium-catalyzed solvent-free conversion of furfural to furfuryl alcohol

“…It is well established that reaction of Ru(acac) 3 and BINAP leads to the formation of Ru(BINAP)(acac) 2 complexes under hydrogen. 31 Since the chelating ring of Ru-BINAP and Ru-DPPB complexes are similar, it is reasonable that the initial step of catalyst activation is formation Ru(DPPB)(acac) 2 , which turns to hydride form Ru(DPPB) 2 (H) 2 under reaction conditions. 32 Due to the six CH 2 units, it can also be assumed that DPPH partially acts as a monodentate ligand in the Ru-center.…”

Electrochemical Fixation of Carbon Dioxide

“…For example, electrochemical carboxylation of 2-allyloxybromobenzene (23) [51,71] followed by enantioselective hydrogenation. For example, electrochemical carboxylation of vinyl bromide 28a yields α, β-unsaturated carboxylic acid 29a in 93 % yield [51], which can be readily transformed into (S)-ibuprofen 27a by enantioselective hydrogenation [78,79] (Scheme 10.10). The precursors of naproxen (29b), ketoprofen (29c), and flurbiprofen (29c) are also synthesized in high yields by similar electrochemical carboxylation.…”