In situ gelatinase-responsive and thermosensitive nanocomplex for local therapy of gastric cancer with peritoneal metastasis

Wang, Xinyue; Gao, Jiahui; Li, Chunhua; Chen, Xu; Li, Xiang; Meng, Fanyan; Liu, Qin; Wang, Qin; Yu, Lan; Liu, Baorui; Wang, Xinyue

doi:10.1016/j.mtbio.2022.100305

Cited by 7 publications

(9 citation statements)

References 28 publications

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“…Similar drug delivery systems have been reported. 9 , 10 , 46 , 47 Gao et al 10 designed an in situ drug-loaded injectable thermosensitive gel system for the simultaneous delivery of norcantharidin-loaded nanoparticles (NCTDNPs) and doxorubicin (Dox) via intratumoral administration to HCC tumors. Drug-loaded gels had good thermal sensitivity and both in vivo and in vitro studies showed that drug-loaded gels significantly inhibited tumor growth.…”

Section: Discussionmentioning

confidence: 99%

Combined Thermosensitive Gel Co-Loaded with Dermaseptin-PP and PTX Liposomes for Effective Local Chemotherapy

Dong¹,

Zhang²,

Wang³

et al. 2023

IJN

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Introduction Chemotherapeutic drugs are often ineffective due to the delivery. Local chemotherapy, which has high drug concentration, low systemic toxicity, and long duration, has shown excellent potential. Cationic antimicrobial peptides have been proved to enhance the tumor cells’ uptake of chemotherapeutic drugs through the membrane-breaking effect. In this study, we designed and developed a thermosensitive gel co-loaded with Dermaseptin-PP and paclitaxel liposomes to increase local chemotherapy. Methods The paclitaxel liposomes were prepared. Then, it was co-loaded with Dermaseptin-PP in a poloxamer-based thermosensitive gel to obtain Dermaseptin-PP/paclitaxel liposomes gel. The thermosensitivity of gels was investigated by test tube inversion method. The rheology was tested by rheometer. The in vitro cytotoxicity and the permeation in tumor of gels were examined by H157 cells and the 3D cell model, respectively. The retention in tumor and antitumor activity of gels were evaluated by H157 tumor-bearing nude mice. Results The particle size of paclitaxel liposomes was 148.97 ± 0.21 nm. The encapsulation rate was 86.1%, and the drug loading capacity was 19.4%. The gels had slow-release and temperature-sensitive properties. The porous 3D network structure of the gels could ensure that the drug was fixed into the tumor. In vitro and in vivo distribution studies showed that Dermaseptin-PP promoted the permeation of the gels in H157 multicellular tumor spheres and achieved longer retention in tumor. In vitro and in vivo antitumor studies demonstrated that Dermaseptin-PP/paclitaxel liposomes gel significantly inhibited the growth of tumors for local chemotherapy with good biosafety. Conclusion This study provided a promising nanomedicine platform for combining antimicrobial peptides and chemotherapeutic drugs for local chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Combined Thermosensitive Gel Co-Loaded with Dermaseptin-PP and PTX Liposomes for Effective Local Chemotherapy

Dong¹,

Zhang²,

Wang³

et al. 2023

IJN

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“…[ 11 , 12 ] When NPs reached tumor sites, the mPEG–PCL conjugates will be cleaved at the certain site of the peptide, and the dePEGylated NPs will interact with tumor cells more effectively, leading to increased cellular uptake of NPs into tumor cells and tumor‐specific activation of CAR‐T cells. [ 13 ] There have been several on‐switch strategies to improve efficacy and safety of CAR‐T therapy. [ 22 ] For example, Stepanov et al.…”

Section: Discussionmentioning

confidence: 99%

Nanomodified Switch Induced Precise and Moderate Activation of CAR‐T Cells for Solid Tumors

Wang

Meng

et al. 2023

Advanced Science

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Chimeric antigen receptor (CAR)-T cell therapy is a transformative treatment against advanced malignancies. Unfortunately, once administrated in vivo, CAR-T cells become out of artificial control, and fierce response to CAR-T therapy may cause severe adverse events, represented by cytokine-release syndrome and on-target/off-tumor effects. Here, a nanomodified switch strategy is developed, leading to sustained and precise "on-tumor only" activation of CAR-T cells. Here, original gelatinase-responsive nanoparticles (NPs) are used to selectively deliver the heterodimerizing switch, which is the key component of switchable CAR with separated activation modules. The "NanoSwitch" is tumor-specific, thus inactivated switchable CAR-T cells do little harm to normal cells, even if the normal cells express the target of CAR-T. Owing to the sustained-release effect of NPs, the CAR-T cells are activated smoothly, avoiding sudden release of cytokine. These data introduce NanoSwitch as a universal and applicable solution to safety problems of CAR-T therapy regardless of the target.

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“…The most widely studied thermo-sensitive hydrogels include poly(N-isopropyl acrylamide) (PNIPAAm) and block copolymer-based materials. [64][65][66][67][68] Wang et al used triblock copolymer PEG-PCL-PEG to load 5-FU and realized the sustained release of 5-FU in the intraperitoneal cavity. 69 The results showed that the 5-FU loaded hydrogel system could better inhibit the peritoneal dissemination of colorectal cancer cells in the intraperitoneal cavity of mice than the 5-FU solution.…”

Section: Chemotherapymentioning

confidence: 99%

“…When the temperature is lower than LCST, the hydrogel exists in a liquid state, and conversely, the material changes from a liquid form to a solid state. The most widely studied thermo‐sensitive hydrogels include poly(N‐isopropyl acrylamide) (PNIPAAm) and block copolymer‐based materials 64–68 . Wang et al.…”

Section: Functional Biomaterials In Psm Treatmentmentioning

confidence: 99%

Functional biomaterials for the diagnosis and treatment of peritoneal surface malignancies

Qin

Guo

et al. 2023

Smart Medicine

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Peritoneal surface malignancies (PSM) can originate from tumors in many organs and are highly malignant, and difficult to diagnose and cure, posing a serious threat to the survival of patients. Although the diagnosis and treatment of PSM have made significant progress in the past two decades, numerous challenges remain. Recently, functionalized biomaterials have shown promise for PSM diagnosis and treatment. Hence, we review the progress of functionalized biomaterials for the diagnosis and treatment of PSM. We first introduce the classification and pathogenesis of PSM. We then discuss the applications of functionalized biomaterials for the diagnosis and treatment of PSM. In particular, we focus on functionalized biomaterials as drug carriers for the treatment of PSM, including chemotherapy, immunotherapy, targeted therapy, combination therapy, and other therapies. Finally, we summarized the current challenges and provided a perspective on the diagnosis and treatment of PSM.

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In situ gelatinase-responsive and thermosensitive nanocomplex for local therapy of gastric cancer with peritoneal metastasis

Cited by 7 publications

References 28 publications

Combined Thermosensitive Gel Co-Loaded with Dermaseptin-PP and PTX Liposomes for Effective Local Chemotherapy

Combined Thermosensitive Gel Co-Loaded with Dermaseptin-PP and PTX Liposomes for Effective Local Chemotherapy

Nanomodified Switch Induced Precise and Moderate Activation of CAR‐T Cells for Solid Tumors

Functional biomaterials for the diagnosis and treatment of peritoneal surface malignancies

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