In situ forming, metal-adhesive heparin hydrogel surfaces for blood-compatible coating

Joung, Yoon Ki; You, Seung Soo; Park, Kyung Min; Go, Dong Hyun; Парк, Ки Донг

doi:10.1016/j.colsurfb.2011.10.047

Cited by 36 publications

(23 citation statements)

References 28 publications

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“…Based on this observation, hydrogel beads prepared by the dropwise addition of a 1% (w/v) succinoglycan solution to a 30 mM Fe 3+ cation solution were used. The diameters of Fe 3+ -SG hydrogel beads were measured using an optical microscope (magnification 10×) [54]. To determine the average bead size, measurements were conducted for randomly 10 beads.…”

Section: Fe 3+ -Sg Hydrogel Bead Preparationmentioning

confidence: 99%

Preparation of Succinoglycan Hydrogel Coordinated With Fe3+ Ions for Controlled Drug Delivery

Jeong

Kim

et al. 2020

Polymers

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Hydrogel materials with a gel-sol conversion due to external environmental changes have potential applications in a wide range of fields, including controlled drug delivery. Succinoglycans are anionic extracellular polysaccharides produced by various bacteria, including Sinorhizobium species, which have diverse applications. In this study, the rheological analysis confirmed that succinoglycan produced by Sinorhizobium meliloti Rm 1021 binds weakly to various metal ions, including Fe2+ cations, to maintain a sol form, and binds strongly to Fe3+ cations to maintain a gel form. The Fe3+-coordinated succinoglycan (Fe3+-SG) hydrogel was analyzed by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, circular dichroism (CD), and field-emission scanning electron microscopy (FE-SEM). Our results revealed that the Fe3+ cations that coordinated with succinoglycan were converted to Fe2+ by a reducing agent and visible light, promoting a gel-sol conversion. The Fe3+-SG hydrogel was then successfully used for controlled drug delivery based on gel-sol conversion in the presence of reducing agents and visible light. As succinoglycan is nontoxic, it is a potential material for controlled drug delivery.

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Section: Fe 3+ -Sg Hydrogel Bead Preparationmentioning

confidence: 99%

Preparation of Succinoglycan Hydrogel Coordinated With Fe3+ Ions for Controlled Drug Delivery

Jeong

Kim

et al. 2020

Polymers

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“…Abbreviations: TTD -Tetronictyramine/dopamine; HT-heparin-tyramine; HPT -heparin-PEG-tyramine. Reprinted from [105] with permission from Elsevier.…”

Section: Improving Blood Compatibilitymentioning

confidence: 99%

Surface modification of stainless steel for biomedical applications: Revisiting a century-old material

Bekmurzayeva

Duncanson

Azevedo

et al. 2018

Materials Science and Engineering: C

191

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Stainless steel (SS) has been widely used as a material for fabricating cardiovascular stents/valves, orthopedic prosthesis, and other devices and implants used in biomedicine due to its malleability and resistance to corrosion and fatigue. Despite its good mechanical properties, SS (as other metals) lacks biofunctionality. To be successfully used as a biomaterial, SS must be made resistant to the biological environment by increasing its anti-fouling properties, preventing biofilm formation (passive surface modification), and imparting functionality for eluting a specific drug or capturing selected cells (active surface modification); these features depend on the final application. Various physico-chemical techniques, including plasma vapor deposition, electrochemical treatment, and attachment of different linkers that add functional groups, are used to obtain SS with increased corrosion resistance, improved osseointegration capabilities, added hemocompatibility, and enhanced antibacterial properties. Existing literature on this topic is extensive and has not been covered in an integrated way in previous reviews. This review aims to fill this gap, by surveying the literature on SS surface modification methods, as well as modification routes tailored for specific biomedical applications.

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“…The encapsulation of bovine chondrocytes into these gels promoted enhanced chondrocyte viability, proliferation, and matrix production, when compared to control hydrogels composed of Dex-TA conjugates alone, demonstrating the potential of Dex–TA/Hep–TA hydrogels as matrices for cartilage tissue engineering. Horseradish peroxidase (HRP)-mediated chemical crosslinking has also been used to prepare in situ forming heparin hydrogel surfaces for blood-compatible coating of metallic biomaterials [76], with significantly enhanced blood compatibility and reduced fibrinogen absorption and platelet adhesion.…”

Section: Heparin Based Hydrogelsmentioning

confidence: 99%

Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications

2014

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Heparin plays an important role in many biological processes, via its interaction with various proteins, and hydrogels and nanoparticles comprising heparin exhibit attractive properties such as anticoagulant activity, growth factor binding, as well as antiangiogenic and apoptotic effects, making them great candidates for emerging applications. Accordingly, this review summarizes recent efforts in the preparation of heparin-based hydrogels and formation of nanoparticles, as well as the characterization of their properties and applications. The challenges and future perspectives for heparin-based materials are also discussed. Prospects are promising for heparin-containing polymeric biomaterials in diverse applications ranging from cell carriers for promoting cell differentiation to nanoparticle therapeutics for cancer treatment.

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In situ forming, metal-adhesive heparin hydrogel surfaces for blood-compatible coating

Cited by 36 publications

References 28 publications

Preparation of Succinoglycan Hydrogel Coordinated With Fe3+ Ions for Controlled Drug Delivery

Preparation of Succinoglycan Hydrogel Coordinated With Fe3+ Ions for Controlled Drug Delivery

Surface modification of stainless steel for biomedical applications: Revisiting a century-old material

Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications

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