In situ forming hydrogel of natural polysaccharides through Schiff base reaction for soft tissue adhesive and hemostasis

Liu, Jia; Li, Jun; Fan, Yu; Zhao, Yaxin; Mo, Xiumei; Pan, Jianfeng

doi:10.1016/j.ijbiomac.2020.01.005

Cited by 100 publications

(33 citation statements)

References 33 publications

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“…A strategy using in situ gelling systems has been used for the transformation of drug/polymer precursor complexes from solution after injection into the human body to gel form by physiological conditions of target tissues or artificial stimuli, such as pH or temperature change, UV irradiation, solvent exchange, catalytic ions, or molecules [ 49 , 50 , 51 ]. Generally, an in situ gelling hydrogel can be synthesized by various chemical reactions, including enzyme-catalyzed cross-linking, Schiff-base reaction, photo-induced polymerization, and Michael-type addition [ 52 , 53 , 54 , 55 ]. This drug delivery system can prevent adverse events in non-target tissues with improved availability of administration.…”

Section: Drug Deliverymentioning

confidence: 99%

Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Park

et al. 2021

Molecules

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Polylactide (PLA) is among the most common biodegradable polymers, with applications in various fields, such as renewable and biomedical industries. PLA features poly(D-lactic acid) (PDLA) and poly(L-lactic acid) (PLLA) enantiomers, which form stereocomplex crystals through racemic blending. PLA emerged as a promising material owing to its sustainable, eco-friendly, and fully biodegradable properties. Nevertheless, PLA still has a low applicability for drug delivery as a carrier and scaffold. Stereocomplex PLA (sc-PLA) exhibits substantially improved mechanical and physical strength compared to the homopolymer, overcoming these limitations. Recently, numerous studies have reported the use of sc-PLA as a drug carrier through encapsulation of various drugs, proteins, and secondary molecules by various processes including micelle formation, self-assembly, emulsion, and inkjet printing. However, concerns such as low loading capacity, weak stability of hydrophilic contents, and non-sustainable release behavior remain. This review focuses on various strategies to overcome the current challenges of sc-PLA in drug delivery systems and biomedical applications in three critical fields, namely anti-cancer therapy, tissue engineering, and anti-microbial activity. Furthermore, the excellent potential of sc-PLA as a next-generation polymeric material is discussed.

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Section: Drug Deliverymentioning

confidence: 99%

Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Park

et al. 2021

Molecules

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“…Failure to haemostasis in time might lead to a lack of oxygen supply, subsequent damage to organs and even life-threatening conditions [277]. The haemostatic activity of MPs dressings is usually achieved by utilising the activity of MPs and their derivatives, as copolymers with other haemostatic materials, and by optimising the coagulation environment [60, [278][279][280]. Some MPs, especially CS, alginate and carrageenan, have excellent haemostatic properties [173,281].…”

Section: Development Of Activities-enhanced Mps Wound Dressingsmentioning

confidence: 99%

Marine Polysaccharides for Wound Dressings Application: An Overview

et al. 2021

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Wound dressings have become a crucial treatment for wound healing due to their convenience, low cost, and prolonged wound management. As cutting-edge biomaterials, marine polysaccharides are divided from most marine organisms. It possesses various bioactivities, which allowing them to be processed into various forms of wound dressings. Therefore, a comprehensive understanding of the application of marine polysaccharides in wound dressings is particularly important for the studies of wound therapy. In this review, we first introduce the wound healing process and describe the characteristics of modern commonly used dressings. Then, the properties of various marine polysaccharides and their application in wound dressing development are outlined. Finally, strategies for developing and enhancing marine polysaccharide wound dressings are described, and an outlook of these dressings is given. The diverse bioactivities of marine polysaccharides including antibacterial, anti-inflammatory, haemostatic properties, etc., providing excellent wound management and accelerate wound healing. Meanwhile, these biomaterials have higher biocompatibility and biodegradability compared to synthetic ones. On the other hand, marine polysaccharides can be combined with copolymers and active substances to prepare various forms of dressings. Among them, emerging types of dressings such as nanofibers, smart hydrogels and injectable hydrogels are at the research frontier of their development. Therefore, marine polysaccharides are essential materials in wound dressings fabrication and have a promising future.

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“…As natural materials they also marked by biodegradability, biocompatibility and low cytotoxicity. Based on polysaccharides that connect using the Schiff-type reactions aldehyde hydroxyethyl starch (AHES) and amino carboxymethyl chitosan (ACC), the rapidly forming in situ hydrogel has a homeostatic ability, which is a particularly attractive property for tissue adhesives [83]. Natural hydrogels are mainly used for articular cartilage tissue engineering due to similar consist of water which is from 60% to 90% for hydrogel and about 70% in ECM of cartilage tissue.…”

Section: Natural Hydrogelsmentioning

confidence: 99%

Bio-Inspired Polymer-Polymer Hybrids for Medical Applications

Demirci¹,

Niedźwiedź²,

Kantor-Malujdy³

et al. 2021

Preprint

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Novel bio-inspired materials have gained recently great attention, especially in medical applications. Applying sophisticated design and engineering methods, various polymer-polymer hybrid systems with outstanding performance have been developed in last decades. Hybrid systems composed of bioelastomers and hydrogels are very attractive due to their high biocompatibility and elastic nature for advanced biomaterials used in various medical applications such as drug delivery systems and scaffolds for tissue engineering. Herein, we describe the advances in current state-of-the-art design, properties and applications of polymer-polymer hybrid systems in medical applications. Bio-inspired functionalities, including bioadhesiveness, injectability, antibacterial properties and degradability applicable to advanced drug delivery systems and medical devices will be discussed in a context of future efforts towards development of bioinspired materials.

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In situ forming hydrogel of natural polysaccharides through Schiff base reaction for soft tissue adhesive and hemostasis

Cited by 100 publications

References 33 publications

Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Marine Polysaccharides for Wound Dressings Application: An Overview

Bio-Inspired Polymer-Polymer Hybrids for Medical Applications

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