In-situ forming drug-delivery systems for periodontal treatment: current knowledge and perspectives

Abstract

Several chemical compounds are considered to be promising as adjuvants in the treatment of periodontitis. Antimicrobials, anti-inflammatory drugs or, more recently, pro-regenerative or antioxidant molecules have shown a very interesting potential to improve the outcomes of mechanical biofilm removal and promote the healing of the damaged tissues. However, their clinical effect is often limited by the challenge of achieving effective and prolonged drug delivery within the periodontal lesion, while limiting the risk of toxicity. In-situ forming implants (ISFI) are ‘implantable’ drug-delivery systems that have gained considerable attention over the last few decades due to their multiple biomedical applications. They are liquids that, when injected at the site to be treated, form a semi-solid or solid dosage form that provides safe and locally controlled drug release. This review discusses current data and future prospects for the use of ISFI in periodontal treatment.

Advances in biomaterials for the treatment of retinoblastoma

“…39 Today, there is a notable emphasis on the chemistry of biodegradable materials in targeted drug delivery applications and numerous developments in biodegradable drug delivery systems have been recently explored, including, in situ drug delivery, cell delivery, gene transfer, site-specific delivery, immunotherapy, and anticancer drug delivery. [145][146][147][148][149] Drug stabilization: The intended biomaterial must provide protection to the embedded drugs and shield them from any breakdown events or degeneracy within the target site, therefore preserving the biological activity of the bioactive factors. 150 In this context, incorporating therapeutic agents into a biomaterial may enhance cell function control and address specific restrictions of conductive and cell-based tissue engineering techniques.…”

“…39 Today, there is a notable emphasis on the chemistry of biodegradable materials in targeted drug delivery applications and numerous developments in biodegradable drug delivery systems have been recently explored, including, in situ drug delivery, cell delivery, gene transfer, site-specific delivery, immunotherapy, and anticancer drug delivery. 145–149…”

Nanoparticle based periodontal drug delivery – A review on current trends and future perspectives

“…Current advances in nanotechnology and nanoparticle based drug delivery approaches have enabled researchers and clinicians achieve the aforementioned goal. Wherein, drug molecules in the form of nanoparticles and scaffolds are encapsulated or loaded onto carriers, which help releasing them in the targeted location in a sustained and controlled manner ( Dubar et al, 2021 ).…”

Smart intraoral systems for advanced drug delivery

“…There are two main subcategories of smart intraoral system (SIS)‐based strategies: transorally mucosal delivery and topical treatment. Transoral mucosal delivery has proven to be a prominent approach to treat xerostomia, hypertension, diabetes, and so on, 17–19 while topical treatment is mainly associated with the therapy of gingivitis, buccal lesions, caries, and bacterial infections, indicating highly clinical values 20–23 . In this review, we systematically summarize the recent development of smart intraoral drug delivery systems based on the advances in the chemical, material, and engineering fields.…”

“…Transoral mucosal delivery has proven to be a prominent approach to treat xerostomia, hypertension, diabetes, and so on, [17][18][19] while topical treatment is mainly associated with the therapy of gingivitis, buccal lesions, caries, and bacterial infections, indicating highly clinical values. [20][21][22][23] In this review, we systematically summarize the recent development of smart intraoral drug delivery systems based on the advances in the chemical, material, and engineering fields. Initially, the anatomical structure and physiological environment of the oral cavity were depicted in detail, followed by material and technique illustrations for SIS fabrication.…”