In situ forming aldehyde-modified xanthan/gelatin hydrogel for tissue engineering applications: synthesis, characterization, and optimization

Aghajanzadeh, Mohamad Sadegh; Imani, Rana; Nazarpak, Masoumeh Haghbin

doi:10.1007/s10853-023-08878-6

Cited by 5 publications

(2 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This faster relaxation coincides with a notable increase in peak stress in the X2/G1 sample, attributed to the presence of a greater number of dangling chains. In our recent publication, 37 we detailed that X2/G1 hydrogel possesses a lower crosslink density, leading to an abundance of dangling chains. We endeavored to enhance the performance of our novel Gel-AXG hydrogels through a series of physical and mechanical tests.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Structural relaxation in a Schiff base‐crosslinked aldehyde modified xanthan gum/gelatin hydrogel: Experimental and numerical validation using linear poroelasticity model

Seresht,

Aghajanzadeh,

Imani

et al. 2024

Polymers for Advanced Techs

Self Cite

View full text Add to dashboard Cite

Hydrogels hold immense promise in biomedical applications due to their biocompatibility, high water content, and versatile fabrication. This study focuses on the mechanical behavior of a novel polysaccharide/protein hybrid hydrogel, GEL‐AXG, synthesized via a Schiff base reaction between aldehyde‐modified xanthan gum (AXG) and gelatin (Gel). Hydrogel samples with varying AXG‐to‐Gel ratios were subjected to unconfined compression tests to assess their mechanical properties. The observed stress‐relaxation mechanism in deformed hydrogels primarily involves water migration. To quantify these mechanical properties, we applied the linear poroelasticity theory. Our results highlight that Gel‐AXG hydrogels with a 2:1 AXG‐to‐Gel ratio exhibit significantly higher peak and equilibrium stresses. This enhancement can be attributed to increased crosslink density and reduced dangling chain presence. Moreover, the linear poroelasticity formulation yielded a shear modulus of G = 44.91 ± 0.25 kPa for Gel‐AXG hydrogels with a 1:2 AXG‐to‐Gel volume ratio, which we identified as our optimized hydrogel.

show abstract

Section: Resultsmentioning

confidence: 99%

“…The Gel-AXG hydrogels were prepared following our prior protocol. 37 In summary, 1 g of xanthan gum was dispersed in 20 mL of ethanol, followed by the gradual addition of 2 mL of a 4 M sodium periodate solution. The mixture was stirred for 6 h at 25 C in the absence of light.…”

Section: Preparation Of Hydrogelsmentioning

confidence: 99%