In Situ-Formed Microparticles of PLGA from O/W Emulsions Stabilized with PVA: Encapsulation and Controlled Release of Progesterone

Abstract

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Investigation of Alogliptin-Loaded In Situ Gel Implants by 23 Factorial Design with Glycemic Assessment in Rats

“…Hence, a lag time was required for the former solvents between injecting the preparation into the buffer release medium and solidification of ISGI formulations leading to a marked fast initial burst release of alogliptin. These findings were in agreement with that stated by Kilicarslan et al [78] and Turino et al [79] where the utilization of low water-miscible solvents could cause no rapid precipitation of the used polymer followed by slow hardening of the injected preparation and incidence of fast initial burst effect. However, the latter highly water-miscible solvents could provide more homogenous gel preparations with low viscosity features that facilitated faster phase inversion dynamics within seconds or minutes during the solvent exchange stage [71].…”

Nanoparticles obtained by confined impinging jet mixer: poly(lactide-co-glycolide) vs. Poly-ε-caprolactone

“…The role of viscosity is generally marginal for solvent displacement in this turbulent regime, differently from what has been proposed using different techniques, like the emulsion polymerization, where the size of the formed droplets may be affected by the polymer solution viscosity [28][29][30].…”

“…Especially in case of PCL, the inverse proportionality is clearly evident (R = 0.922), at least in the investigated range. It is well known that reducing the size distribution of dispersion, stability is increased because sedimentation or cremation effects are reduced [30]. In this case, the effect is counteracted by zeta potential variation, because for smaller sizes the absolute zeta values decrease.…”

Comparison of Doxycycline Hyclate Release from Beta-Cyclodextrin Based <i>In Situ</i> Forming Systems for Periodontal Pocket Targeting

“…In case of solvent exchange, the transformation step of ISG was instantly occurred after injection in single step when solution directly contacted with physiological fluid at target site [5,6]. ISM had two steps of transformation including the diffusion of physiological fluid through external phase and then into internal phase to initiate the microparticles formation [7][8][9]. The drug release was occurred in both of emulsion stage and microparticle stage with continuously change in the transformation process.…”

“…ISG is a polymeric solution that transforms into gel or matrix-like after contact with aqueous environment [5,6]. ISM is an emulsion comprising internal phase as a polymeric solution dispersed in oil phase that transforms into microparticles after injection and exposure to an aqueous environment [7][8][9]. Beta-cyclodextrin (β-CD) is hydrophilic surface with hydrophobic cavity.…”