In situ formation of silver nanoparticles in linear and branched polyelectrolyte matrices using various reducing agents

Chumachenko, V.; Kutsevol, N.; Rawiso, M.; Schmutz, Marc; Blanck, Christian

doi:10.1186/1556-276x-9-164

Cited by 28 publications

(27 citation statements)

References 30 publications

(14 reference statements)

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“…The branched polymers, due to their more compact molecular structure, have a higher local concentration of functional groups in comparison to their linear analogs. These structure peculiarities of branched polymers are advantageous for application in nanotechnologies [25,26].…”

Section: Resultsmentioning

confidence: 99%

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Dextran-Polyacrylamide as Matrices for Creation of Anticancer Nanocomposite

Телегеев

Kutsevol

Chumachenko

et al. 2017

International Journal of Polymer Science

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Drug targeting to specific organs and tissues is one of the crucial endeavors of modern pharmacotherapy. Controlled targeting at the site of action and reduced time of exposure of nontargeted tissues increase the efficacy of the treatment and reduce toxicity and side effects, improving compliance and convenience. Nanocarriers based on the branched copolymers dextran-graft-polyacrylamide were synthesized and characterized and were tested on phagocytic cells. It was shown that these nanoparticles are actively captured by phagocytic cells and that they are not cytotoxic. The polymer nanoparticles loaded with cisplatin at different concentrations from 0.1 to 10 μg/mL yielded dose-dependent decrease in viability of chronic myelogenous leukemia and histiocytic lymphoma cells. The lowest percentage of viable cells was observed for lymphoma cells (22%). Taking into account the fact that our nanoparticles will act mainly on malignant phagocytic cells and do not affect healthy cells, they can thus potentially be used for the therapeutic treatment of tumor cells having phagocytic activity. The effect of nanosilver on cell viability was lower than the one of polymer/cisplatin composite. The data from the cytotoxic studies indicate that nanosilver induces toxicity in cells. However, when the copolymers were conjugated to both nanosilver and cisplatin, such a nanosystem displayed less cytotoxic effect compared to the conjugates of dextran-polyacrylamide and cisplatin.

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Section: Resultsmentioning

confidence: 99%

“…The choice of this copolymer among the series of the branched samples synthesized based on our previous research. Namely, this sample was the most efficient polymer matrices for Ag sol in situ synthesis as well as for the nanoscale catalyst preparation [25,26].…”

Section: Polymer Nanocarriersmentioning

confidence: 99%

Dextran-Polyacrylamide as Matrices for Creation of Anticancer Nanocomposite

Телегеев

Kutsevol

Chumachenko

et al. 2017

International Journal of Polymer Science

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“…This copolymer has star-like structure consisting of a compact dextran core and long polyacrylamide arms [14,15]. It was reported in our previous study that branched polymers were much more efficient for the synthesis of silver nanoparticles [16][17][18]. The structure peculiarities of branched polymers caused a higher local concentration of functional groups in comparison with their linear analogue, giving the advantages for the application of branched polymers as matrices in nanotechnologies.…”

Section: Methodsmentioning

confidence: 99%

“…Original solutions were diluted 25 times before spectral measurements. The estimation of the average sizes of nanoparticles from the absorption spectra was performed using the effective mass approximation [17,18].…”

Section: Characterizationmentioning

confidence: 99%

Synthesis and Characterization of CdS Nanoparticles Obtained in Star-Like Dextran-Graft-Polyacrylamide Matrices

Naumenko¹,

Str.²,

Kutsevol³

et al. 2017

Ukr. J. Phys.

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Cadmium sulfide (CdS) nanoparticles (NPs) are synthesized into a branched dextran-graftpolyacrylamide matrix. The obtained stable sol is characterized by spectrophotometry, fluorescence spectroscopy, transmission electron microscopy, and dynamic light scattering. The polymer affects the process of the nanoparticle formation, namely controls their size and morphology, and enhances the sols storage stability preventing the nanoparticles aggregation. It is shown that CdS NPs obtained in a branched polymer matrix are monodisperse 4-6 nm in size and form clusters (50-200 nm in size) localized in a limited macromolecule volume. The CdS nanoparticles reveal the improved blue light emission and may be considered as a promising material for light-emitting devices, especially in the blue region. They may have potential applications as biological labels.

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“…Під керівництвом д-ра хім. наук Н. В. Куцевол [72][73][74][75][76][77][78] вивчаються розгалужені водорозчинні полімери, які відповідають теоретичним моделям сферичних і циліндричних полімерних щіток. Було синтезовано й досліджено кополімери декстран-поліакриламід та декстран сульфат-поліакриламід та їхні аніонні похідні.…”

Section: д г вишневський)unclassified

From Organics to Polymers

Kolendo

Savchenko

Vretik

et al. 2017

Bull. T. Shevchenko Nat. Univ. Kyiv. Chem.

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Polymers, composites, their components and complexes for application in information tecnologies and biotechnology as well as for medicine and solar energy transfer have been obtained. In particular, new high-resolution photochromic polymer materials with a significant nonlinear optical effect of the third order have been developed. They are perspective for the creation of high-speed optical switches in optical recording and information storage. A new way of recording information based on the generation of the second harmonic with new photochromic polymers has been found. The perspectivity of alken-functionalised poly(phenyl/naphthylmethacrylates) as basic compounds for polarization-sensitive polymeric media was prooved.The chemical modification of polymers by benzenesulfonamide derivatives for biostabilization of plastic masses and providing hydrophilic properties for their surface was carried out. A fundamentally new approach is developed in which processes of energy transfer of excited states in polymer macromolecule to the photostabilaser are used for effective stabilization of polymer materials. Thermostabilized samples of polystyrene with covalently bonded of imidophenylmethacrylates have been developed. The branched copolymers are highly efficient matrices for the synthesis of stable gold, silver, CdS and Au / CdS nanoparticles and copolymers that can be used as nanovectors for the target delivery of highly toxic antitumor drugs. New effective preparations for desinfaсtion of fish nurseries, dressing and hygienic materials, linen and clothes have been developed.

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In situ formation of silver nanoparticles in linear and branched polyelectrolyte matrices using various reducing agents

Cited by 28 publications

References 30 publications

Dextran-Polyacrylamide as Matrices for Creation of Anticancer Nanocomposite

Dextran-Polyacrylamide as Matrices for Creation of Anticancer Nanocomposite

Synthesis and Characterization of CdS Nanoparticles Obtained in Star-Like Dextran-Graft-Polyacrylamide Matrices

From Organics to Polymers

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