In situ formation of injectable organogels for punctal occlusion and sustained release of therapeutics: design, preparation, in vitro and in vivo evaluation

Cao, Zehong; Chen, Yangnan; Bai, Shaoyun; Zheng, Zhiyun; Liu, Yan; Gui, Shuangying; Shan, Shuang; Wu, Jiabao; He, Ning

doi:10.1016/j.ijpharm.2023.122933

Cited by 8 publications

(2 citation statements)

References 46 publications

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“…In the dynamic landscape of pharmaceutical formulation, the unique fatty acid composition of SO emerges as a beacon of innovation, particularly in the realm of sustained-release formulations [123]. Rich in polyunsaturated fats, SO offers a versatile lipid matrix that can be harnessed to control the release rate of drugs, paving the way for prolonged therapeutic effects and the potential for reduced dosing frequency [124].…”

Section: Sustained-release Formulationsmentioning

confidence: 99%

Soybean Oil: A Versatile Asset in Pharmaceutical Drug Delivery

Mohanty,

Behera,

Kumar Shaw

et al. 2024

Agricultural Sciences

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Soybean oil (SO), a lucrative and widely utilized vegetable oil, is used not only in the pharmaceutical industry but also to produce green diesel and several biomedical applications. SO is rich in healthy fats, including linoleic acid (54%), oleic acid (23%), palmitic acid (11%), linolenic acids (8%), and stearic acid (4%). Its high unsaturated fatty acid content makes it ideal for medicinal purposes. In topical application, SO provides anti-inflammatory and soothing benefits. The presence of SO in lipid-based medication improves the therapeutic efficacy and bioavailability of poorly water-soluble drugs. Its emulsifying properties support the development of Self-Emulsifying Drug Delivery Systems (SEDDS) and Self-Micro Emulsifying Drug Delivery Systems (SMEDDS), helping the oral administration of hydrophobic drugs. Additionally, soybean oil is included in total parenteral nutrition (TPN) solutions to provide essential fatty acids to patients unable to swallow. SO, biocompatibility, stability, and low toxicity make it a brilliant base for transcutaneous and topical delivery systems, enlightening the absorption of active medicinal ingredients. In gist, unique properties and a wide variety of applications make SO a star material in pharmaceuticals to enhance solubility, bioavailability, and the development of safe and effective drugs.

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Section: Sustained-release Formulationsmentioning

confidence: 99%

Soybean Oil: A Versatile Asset in Pharmaceutical Drug Delivery

Mohanty,

Behera,

Kumar Shaw

et al. 2024

Agricultural Sciences

View full text Add to dashboard Cite

show abstract

“…26 This mesmerizing domain has the inherent capacity to yield functionalized materials with tangible applications encompassing diverse fields, including materials science and biomedicine, drug delivery, tissue engineering and therapeutics, and other innovative pursuits. [26][27][28] Some of the innovative applications including self-healing electrically conductive organogel, delivery vehicles for the stabilization of organo-lithium reagents, improvement in in situ electrical conductivity, wastewater treatment, and organogels for art conservation are recognized in the literature. [29][30][31][32][33] Thus, organogels can be designed to exhibit specific properties based on the choice of gelator molecules and solvents.…”

Section: Introductionmentioning

confidence: 99%