In situ fabrication of microporous organic network coated capillary column for high resolution gas chromatographic separation of hydrocarbons

Cui, Yuanyuan; Yao, Huan; Yang, Cheng‐Xiong; Yan, Xiu‐Ping

doi:10.1002/elps.201800540

Cited by 8 publications

(2 citation statements)

References 25 publications

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“…In recent years, MONs have exhibited great potential in the fields of gas storage [22,23], contaminant removal [24,25], extraction [26], and sensing [27], owing to their good chemical and thermal stabilities, large surface area, and facile post-functionalization. Such properties, along with their desirable hydrophobicities, render MONs as very promising in separation science, to be used from sample pretreatment to chromatography [28][29][30][31][32][33]. For instance, Jia [32] prepared MOF@MON composites to improve the SPME of aromatics from environmental water, particulate matter (PM 2.5 ), and food samples.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, Jia [32] prepared MOF@MON composites to improve the SPME of aromatics from environmental water, particulate matter (PM 2.5 ), and food samples. Our group has reported the fabrication of MON-and chiral-MON-coated capillary columns for GC separation of small alkanes and chiral alcohols [29,30]. Du and Yu et al also reported the fabrication of MON@SiO 2 composites as novel stationary phases for the HPLC separation of diverse aromatics [31,33].…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of microporous organic network@silica composite for high‐performance liquid chromatographic separation of drugs and proteins

2021

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Microporous organic networks (MONs) that exhibit good stability and hydrophobicity are promising candidates for performing HPLC separation of small organic compounds. However, their applications in separating large analytes as well as biomolecules are still limited by the microporous nature of MONs. Herein, we demonstrated the fabrication of a MON-functionalized silica (MON@SiO 2 ), exhibiting micro and mesopores for the HPLC separations of small drugs as well as large analytes, such as flavones, nonsteroidal anti-inflammatory drugs (NSAIDs), endocrine disrupting chemicals (EDCs), and proteins. MON was successfully modified on SiO 2 microspheres to yield the uniform and mono-dispersed MON@SiO 2 . The separation mechanisms and performance of the MON@SiO 2 packed column were evaluated for a wide range of analytes, including neutral, acidic, basic compounds, drugs, and proteins. Compared with commercial C18 and SiO 2 -NH 2 packed columns, the proposed MON@SiO 2 column afforded superior performance in the separations of flavones, NSAIDs, EDCs, and proteins. Moreover, the MON@SiO 2 column also offered good repeatability with intraday RSDs (n = 7) of <0.1%, <2.0%, <2.3%, and <0.7% for the retention time, peak height, peak area, and half peak width, respectively, for separating EDCs. This work proved the potential of using MONs in the HPLC separations of drugs and proteins.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fabrication of microporous organic network@silica composite for high‐performance liquid chromatographic separation of drugs and proteins

2021

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Chiral amorphous metal–organic polyhedra used as the stationary phase for high‐resolution gas chromatography separations

et al. 2020

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Herein, we describe a new chiral amorphous metal–organic polyhedra used as the stationary phase for high‐resolution gas chromatography (GC). The chiral stationary phase was coated onto a capillary column via a dynamic coating process and investigated for a variety of compounds. The experimental results showed that the chiral stationary phase exhibits good selectivity for linear alkanes, linear alcohols, polycyclic aromatic hydrocarbons, isomers, and chiral compounds. In addition, the column has the advantages of high column efficiency and short analysis time. The present work indicated that amorphous metal–organic polyhedra have great potential for application as a new type of stationary phase for GC.

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Preparation of alkyl microporous organic network‐based capillary column for an efficient gas chromatographic separation of position isomers

Gao,

Li,

Cui

et al. 2024

Electrophoresis

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The large surface area, excellent thermal stability and easy modification make microporous organic networks (MONs) good candidates in the field of gas chromatography (GC). Due to the limited species and highly conjugated networks of MONs, their applications are still in infancy and restricted. To accelerate their developments and to enrich their types in GC, here we report the first example of synthesizing alkyl MON and its capillary column for GC separation of position isomers. Linear 1,8‐dibromooctane is used as the alkyl monomer instead of traditional aromatic ones to construct novel alkyl MON to decrease the inherent conjugated characteristic of MONs. The alkyl MON exhibits good thermal stability (up to 350°C), large surface area (1173 m2 g−1), and non‐polar character, allowing good resolution for alkanes, alkyl benzenes, alcohols, ketones, and diverse position isomers, including dichlorobenzene, trichlorobenzene, bromotoluene, nitrotoluene, methylbenzaldehyde, and ionone with the limits of detection (0.003 mg mL−1) and limits of quantitation of (0.10 mg mL−1). The in situ growth–prepared alkyl MON column demonstrates remarkable duration time and precisions for the retention relative standard deviations, (RSDs%, intra‐day, n = 7), 0.06%–0.53% (intra‐day, n = 7), and 2.87%–10.59% (column‐to‐column, n = 3). In addition, the fabricated alkyl MON‐coated capillary column offers better resolution than three commercial GC columns for the resolution of methylbenzaldehyde, bromotoluene, and chlorotoluene isomers. This work reveals the practicability for synthesizing alkyl MONs and demonstrates their prospects for position isomers separation.

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In situ fabrication of microporous organic network coated capillary column for high resolution gas chromatographic separation of hydrocarbons

Cited by 8 publications

References 25 publications

Fabrication of microporous organic network@silica composite for high‐performance liquid chromatographic separation of drugs and proteins

Fabrication of microporous organic network@silica composite for high‐performance liquid chromatographic separation of drugs and proteins

Chiral amorphous metal–organic polyhedra used as the stationary phase for high‐resolution gas chromatography separations

Preparation of alkyl microporous organic network‐based capillary column for an efficient gas chromatographic separation of position isomers

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