In situ evaluation of low-fluoride toothpastes associated to calcium glycerophosphate on enamel remineralization

Anticaries effect of low-fluoride dentifrices with phosphates in children: A randomized, controlled trial

“…Contradictory evidence was also shown for formulations containing CaGP: while the anticaries effect of a 1000 mg F/g toothpaste (as MFP) was significantly enhanced by the addition of 0.13% CaGP [23], an in situ study showed no additional protective effect of a 1500 mg F/g toothpaste (MFP) when 0.13% CaGP was added to the formulation [24]. Unlike the above-mentioned formulations, the present study tested the addition of polyphosphate salts to dentifrices with low fluoride content (containing NaF as the fluoride source), in which the optimum molar ratios between fluoride and TMP or CaGP had been previously determined in vitro [9][10][11] and confirmed in situ [12][13][14].…”

“…The addition of sodium trimetaphosphate (TMP) to a LFD (500 ppm F) was shown to significantly reduce enamel mineral loss when compared to a conventional dentifrice in vitro [9,11] and in situ [12]. Similarly, the addition of calcium glycerophosphate (CaGP) to a LDF promoted similar anticaries effect to that attained after using a conventional dentifrice, according to in vitro [10] and in situ [13,14] studies. Despite the promising results reported for TMP-and CaGP-containing toothpastes, no clinical evidence is still available to attest the anticaries effects of LFDs supplemented with phosphate salts on the progression of caries lesions.…”

Remineralizing Potential of a Low Fluoride Toothpaste with Sodium Trimetaphosphate: An in situ Study

“…For 1,100 ppm F toothpaste, the high levels of F in enamel resulted from the higher F concentration in the product (when compared with the TMP-containing toothpaste), which leads to an increase in enamel Ca and Pi [do Amaral et al, 2013;Zaze et al, 2014]. However, the higher mineral composition resulting from 1,100 ppm F produced a more marked effect in outer regions of subsurface lesions (as evidenced by the differential hardness profiles), since F presents a remineralizing effect on the most superficial area of the lesion [Danelon et al, , 2014.…”

Noninvasive Dentistry: A Dream or Reality?

“…Pulsing together with or after a sucrose pulse was less effective in reducing demineralization. Zaze et al [2014] showed in an in situ study that adding 0.25% Ca-GP to a 500-ppm F dentifrice resulted in enhanced remineralization compared to a 500-ppm F dentifrice. The F-Ca-GP combination resulted in a similar mineral gain than a 1,100-ppm F dentifrice.…”