In situ endocrine disrupting effects of cadmium on the reproduction of Ruditapes decussatus

Ketata, I.; Smaoui-Damak, W.; Guermazi, F.; Rebaï, Tarek; Hamza-Chaffai, Amel

doi:10.1016/j.cbpc.2007.05.002

Cited by 22 publications

(15 citation statements)

References 67 publications

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“…Sediment contaminants could be released to the overlying water, resulting in potential adverse health effects to aquatic organisms (Daskalakis and O'Connor, 1995;Delorenzo, 1997;Freret-Meurer et al, 2010). Among the adverse health effects associated with these contaminants are toxicity to the kidney, nervous and reproductive systems, as well as endocrine disruption and mutations (Collier et al, 1998;Nirmala et al, 1999;Ketata et al, 2007;Liu et al, 2008;Brar et al, 2009). In addition, trace metals are known to bioaccumulate in edible aquatic organisms (e.g., mollusks), thus, representing a health risk to top predators, including humans (Fox et al, 1991;Renzoni et al, 1998;Huang et al, 2006;Díez et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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El‐Serehy¹,

Aboulela²,

Al‐Misned³

et al. 2012

Turk. J. Fish. Aquat. Sci.

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The concentrations of Fe, Mn, Zn, Cu, Pb and Cd in bottom sediment and surface water in the Egyptian coastal waters along the Mediterranean Sea, and thence the soft tissues of the bivalve (Donax trunculus) were determined. The mean concentrations (µg g -1 ) of heavy metals in bottom sediment were as follows: Fe: 1748.2-2030, Mn: 191.4-254.3, Zn: 28-42.2, Cu: 4-9.4, Pb: 18.4-24.8, Cd: 1.4-2.3, and in surface water: Fe: 744-896, Mn: 162-198, Zn: 242.6-300, Cu: 12.6-19.3, Pb: 31.3-56, Cd: 0.8-3.1,while in soft tissues of the bivalve D. trunculus, the mean concentrations (µg g -1 dry weight) were as follows: Fe: 47.2-66.4, Mn: 4.8-8.4, Zn: 22-36.4, Cu: 3.2-4.8, Pb: 5.6-9.2, Cd: 1.6-2.4. The present study has revealed that the concentrations of Cd and Pb in the soft tissues of the edible bivalve D. trunculus were above the maximum acceptable concentrations for human consumption proposed by FAO/WHO, EU. Moreover, estimation of concentration factor (C f ) for the studied metals in the soft tissues of the edible bivalve D. trunculus recorded high accumulation rates of Cd and Cu. The present study confirmed that, the examined bivalve species was associated with enhanced metal content in its soft tissues and was not safe within the limits for human consumption. Water and bottom sediments showed apparent seasonal variations of metals accumulation with maximum concentrations during summer and winter, respectively. Mean metal concentrations were found to be higher in some of the selected five sites than others, but, these differences in heavy metal concentrations were not statistically significant (P>0.05), suggesting that common and main anthropogenic sources contributing to the heavy metal pollution at this Egyptian coastal area on the Mediterranean sea. The results obtained in this study were compared with those reported in earlier studies and concluded that, the area of the present study was in general not considered a metal polluted area according to the OME and EPA classification criteria. However, concentrations of Cd and especially, Pb did give some cause for concern, and warrants a continued monitoring programme for inorganic and chemical organic compounds in sediments, water, and biota along the Egyptian Mediterranean coasts.

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Section: Introductionmentioning

confidence: 99%

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El‐Serehy¹,

Aboulela²,

Al‐Misned³

et al. 2012

Turk. J. Fish. Aquat. Sci.

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“…The metals, present in their available forms in tested effluent, were taken up and bioaccumulate by clams. Cadmium is known to have endocrine-disrupting effect in clams R. decussatus (Ketata et al 2007) and in other species of bivalves (Henson and Chedrese 2004;Rodríguez et al 2007). Potential mechanisms by which cadmium may acts as an EDC are its interference with DNA binding Zn-finger motif though the substitution of Cd for Zn or by mimicking or inhibiting the action of endogenous estrogens (Henson and Chedrese 2004).…”

Section: Discussionmentioning

confidence: 98%

“…Research and development activities have focused on EDCs in rivers, lakes (Louiz et al 2008;Mnif et al 2012), and lagoons (Lahbib et al 2010;Abidli et al 2012). However, to the best of our knowledge, there are only two studies concerning the gulf of Gabes area (Ketata et al 2007;Kessabi et al 2013) which is considered as one of the most productive ecosystem in Tunisia in which the bivalve Ruditapes decussatus represent an important economic resource.…”

Section: Introductionmentioning

confidence: 97%

The endocrine-disrupting effect and other physiological responses of municipal effluent on the clam Ruditapes decussatus

Mezghani-Chaari

Machreki-Ajmi

Trémolet

et al. 2015

Environ Sci Pollut Res

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In order to document the potential endocrine disrupting and toxic effect of the municipal wastewater effluents discharged into the Sfax coastal area (South of Tunisia), specimens of clam R. decussatus were collected from a reference site and were in vivo exposed to treated sewage effluent for 30 days. To this end, estrogenic and androgenic activities were measured in the gills to assess potential accumulation and regulation of active compounds. After effluent exposure androgenic activity in organic extracts increased up to fivefold compared to controls and remained elevated, while estrogenic activity was not significantly affected by exposure. As a consequence, remarkable disruptions in the gametogenesis activity, glycogen content, and Vitellogenin-like protein levels in male clams were observed. A parallel analysis of heavy metals in clam tissues was determined. A significant uptake of Ni, Zn, and Pb in soft tissues of exposed clams was observed. The significant increase of malondialdehyde (MDA) concentrations as a function of exposure time implies that clams have been exposed to an oxidative stress probably due to the presence of high metal concentrations in sewage effluent. Correlation analysis has revealed a statistically significant and positive relationship between MDA levels and metal concentrations in clams' tissues. The acetylcholinesterase activity was not significantly affected by exposure. Altogether, these results showed that a short-term exposure to a mixture of chemical compounds released by the Sfax wastewater treatment plant induce adverse physiological and reproductive effects in R. decussatus. Further studies are underway in order to evaluate its long-term impacts on aquatic wildlife in the gulf of Gabes area.

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“…Moreover, R. decussatus satisfies many criteria required for a biological indicator species (HamzaChaffai et al 2000). Taking into consideration both the economic and scientific importance of R. decussatus in Tunisia, many studies have been conducted in order to understand the biology of this clam and especially its gametogenic cycle better (Trigui-El Mnif 1995;Hamida 2004;Hamida et al 2004;Smaoui-Damak et al 2006;Ketata et al 2007). Reproductive activity in marine bivalves is supported by the mobilization of energy reserves which are stored at different times of the year, depending on the species and on its localization.…”

Section: Introductionmentioning

confidence: 98%

Storage and reproductive strategy of the carpet-shell clam,Ruditapes decussatusin the Gulf of Gabès (Tunisia)

Smaoui-Damak

Guebsi

Karray

et al. 2012

Invertebrate Reproduction & Development

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In this study, the variations of glycogen concentrations in Ruditapes decussatus from Sfax coasts (Tunisia) were described in relation to the reproductive cycle. Separate analyses were made of gonad, adductor muscle and 'remainder'. The timing of gametogenic development and spawning was evaluated using qualitative histology associated with image analysis including (1) the estimation of the gonadal occupation index (GOI), (2) surface area occupied by reserve tissues and (3) variation in oocyte diameter. The reproductive cycle of R. decussatus exhibited partial asynchronization between sexes, the major difference being observed in the duration of the spawning period. Contrary to previous studies, we observed continuous partial spawning (e.g. 50% of ripe oocytes still subsisted at the partial spawning stage). During the gametogenic cycle, GOI varied significantly in males and in females. Most oocytes were ripe and ready to spawn when their diameter reached or exceeded 45 mm. The expansion of gonad was inversely proportional to the development of the foot tissue. Glycogen concentration showed significant temporal variations between tissues, indicating the clear differentiation in energy storage between the clam organs.

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In situ endocrine disrupting effects of cadmium on the reproduction of Ruditapes decussatus

Cited by 22 publications

References 67 publications

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The endocrine-disrupting effect and other physiological responses of municipal effluent on the clam Ruditapes decussatus

Storage and reproductive strategy of the carpet-shell clam,Ruditapes decussatusin the Gulf of Gabès (Tunisia)

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