In situ electrospun aloe-nanofiber membrane for chronic wound healing

Liu, Chang; Wang, Yun; Wang, Pei; Gong, Yan; Yi, Baolian; Ruan, Jing; Wang, Xiansong

doi:10.1016/j.smaim.2023.03.003

Cited by 9 publications

(2 citation statements)

References 30 publications

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“…Local administration is an important option that can effectively improve the concentration of engineered therapeutic bacteria at the tumor side and reduce the potential side effects of local systemic infection [ 40 ]. As the rapid development of materials science, hydrogels have been developed for bacteria-mediated therapy, such as bacterial-promoted wound healing, bacterial vaccines and probiotic-mediated digestive treatment [ [41] , [42] , [43] ]. For cancer bacteria immunotherapy, hydrogel depots based on alginate can load engineered bioluminescent bacteria and Ce6 for self-activated PDT and systemic anticancer immunity boost [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Injectable thermo-sensitive hydrogel enhances anti-tumor potency of engineered Lactococcus lactis by activating dendritic cells and effective memory T cells

Chen,

Zhu,

Liu

et al. 2024

Bioactive Materials

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Section: Discussionmentioning

confidence: 99%

Injectable thermo-sensitive hydrogel enhances anti-tumor potency of engineered Lactococcus lactis by activating dendritic cells and effective memory T cells

Chen,

Zhu,

Liu

et al. 2024

Bioactive Materials

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“…This phenomenon could explain why cells form robust adhesions, even on softer fibrous patterns. The fibrous patterns not only manipulate the initial position but also guide the extension direction of focal adhesions. , In the process of cell spreading, the cellular actomyosin cytoskeleton connects to the focal adhesions and changes the extended direction. Enhanced intracellular traction forces through focal adhesions attempt to change the topology of the substrates.…”

Section: Hydrogels With Aligned and Random Topographiesmentioning

confidence: 99%

Synergistic Influence of Fibrous Pattern Orientation and Modulus on Cellular Mechanoresponse

Sun,

Pan,

Wang

et al. 2024

Nano Lett.

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The fibrous extracellular matrix (ECM) is vital for tissue regeneration and impacts implanted device treatments. Previous research on fibrous biomaterials shows varying cellular reactions to surface orientation, often due to unclear interactions between surface topography and substrate elasticity. Our study addresses this gap by achieving the rapid creation of hydrogels with diverse fibrous topographies and varying substrate moduli through a surface printing strategy. Cells exhibit heightened traction force on nanopatterned soft hydrogels, particularly with randomly distributed patterns compared with regular soft hydrogels. Meanwhile, on stiff hydrogels featuring an aligned topography, optimal cellular mechanosensing is observed compared to random topography. Mechanistic investigations highlight that cellular force-sensing and adhesion are influenced by the interplay of pattern deformability and focal adhesion orientation, subsequently mediating stem cell differentiation. Our findings highlight the importance of combining substrate modulus and topography to guide cellular behavior in designing advanced tissue engineering biomaterials.

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Macrophage plasticity: signaling pathways, tissue repair, and regeneration

Yan,

Wang,

Cai

et al. 2024

MedComm

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Macrophages are versatile immune cells with remarkable plasticity, enabling them to adapt to diverse tissue microenvironments and perform various functions. Traditionally categorized into classically activated (M1) and alternatively activated (M2) phenotypes, recent advances have revealed a spectrum of macrophage activation states that extend beyond this dichotomy. The complex interplay of signaling pathways, transcriptional regulators, and epigenetic modifications orchestrates macrophage polarization, allowing them to respond to various stimuli dynamically. Here, we provide a comprehensive overview of the signaling cascades governing macrophage plasticity, focusing on the roles of Toll‐like receptors, signal transducer and activator of transcription proteins, nuclear receptors, and microRNAs. We also discuss the emerging concepts of macrophage metabolic reprogramming and trained immunity, contributing to their functional adaptability. Macrophage plasticity plays a pivotal role in tissue repair and regeneration, with macrophages coordinating inflammation, angiogenesis, and matrix remodeling to restore tissue homeostasis. By harnessing the potential of macrophage plasticity, novel therapeutic strategies targeting macrophage polarization could be developed for various diseases, including chronic wounds, fibrotic disorders, and inflammatory conditions. Ultimately, a deeper understanding of the molecular mechanisms underpinning macrophage plasticity will pave the way for innovative regenerative medicine and tissue engineering approaches.

show abstract

In situ electrospun aloe-nanofiber membrane for chronic wound healing

Cited by 9 publications

References 30 publications

Injectable thermo-sensitive hydrogel enhances anti-tumor potency of engineered Lactococcus lactis by activating dendritic cells and effective memory T cells

Injectable thermo-sensitive hydrogel enhances anti-tumor potency of engineered Lactococcus lactis by activating dendritic cells and effective memory T cells

Synergistic Influence of Fibrous Pattern Orientation and Modulus on Cellular Mechanoresponse

Macrophage plasticity: signaling pathways, tissue repair, and regeneration

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