Diabetes mellitus is a metabolic chronic disease characterized by persistent hyperglycemia resulting in oxidative stress. Excessive production of reactive oxidative species (ROS) through the mitochondrial electron transport chain and other pathways destroys the macromolecules such as proteins, lipids, and DNA thereby leading to an inflammatory response involving the excessive production of cytokines, which leads to the augmentation of the production of ROS and subsequently leads to tissue damage. One of the complications of diabetes mellitus is male infertility which results from reproductive tissue damage. Oxidative stress and chronic inflammation in the male reproductive tissue pose a great risk in the development of male infertility. Although, synthetic drugs are conventionally used in the treatment of diabetes and its complications, the cost implications and adverse effects associated with the use of the drugs cannot be overemphasized. Hence, the quest for cost-effective alternative with fewer side effects such as natural products are highly imperative. Therefore, the present review aimed at providing available ethnobotanical information about medicinal plants used in Thengwe, Limpopo Province in the management of diabetes and its complications such as male infertility.