In situ compressibility of carbonated hydroxyapatite in tooth dentine measured under hydrostatic pressure by high energy X-ray diffraction

Forien, Jean‐Baptiste; Fleck, Claudia; Krywka, Christina; Zolotoyabko, E.; Zaslansky, Paul

doi:10.1016/j.jmbbm.2015.06.005

Cited by 15 publications

(15 citation statements)

References 44 publications

(55 reference statements)

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“…The model results showed that the elastic modulus of the crystals, i.e., their resistance to elastic deformation, decreased with increasing carbonate substitution. These results are in agreement with previous work that has shown that biological bone apatites, which contain carbonate, have a lower modulus compared to carbonate-poor geological apatites [79, 80]. If bone is considered to be a composite of mineral and collagen, changes to the mineral stiffness and fracture strength due to composition and size effects, as seen here, will have significant consequences for the overall bone mechanics.…”

Section: Discussionsupporting

confidence: 92%

Protein-free formation of bone-like apatite: New insights into the key role of carbonation

et al. 2017

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The nanometer-sized plate-like morphology of bone mineral is necessary for proper bone mechanics and physiology. However, mechanisms regulating the morphology of these mineral nanocrystals remain unclear. The dominant hypothesis attributes the size and shape regulation to organic-mineral interactions. Here, we present data supporting the hypothesis that physicochemical effects of carbonate integration within the apatite lattice control the morphology, size, and mechanics of bioapatite mineral crystals. Carbonated apatites synthesized in the absence of organic molecules presented plate-like morphologies and nanoscale crystallite dimensions. Experimentally-determined crystallite size, lattice spacing, solubility and atomic order were modified by carbonate concentration. Molecular dynamics (MD) simulations and density functional theory (DFT) calculations predicted changes in surface energy and elastic moduli with carbonate concentration. Combining these results with a scaling law predicted the experimentally observed scaling of size and energetics with carbonate concentration. The experiments and models describe a clear mechanism by which crystal dimensions are controlled by carbonate substitution. Furthermore, the results demonstrate that carbonate substitution is sufficient to drive the formation of bone-like crystallites. This new understanding points to pathways for biomimetic synthesis of novel, nanostructured biomaterials.

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Section: Discussionsupporting

confidence: 92%

Protein-free formation of bone-like apatite: New insights into the key role of carbonation

et al. 2017

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“…The Ca/P ratio was 1.67 for TMPmicro and 1.68 for TMPnano (Table 2), which may be assumed to be alike hydroxyapatite [34]. The control group presented a Ca/P ratio of 1.57, which would indicate the presence of carbonated apatite [35] that composes the mineral part of dentin [36]. The immersion of dentin in saliva (human and artificial) led to precipitation of calcium phosphate no-apatite (placebo group), which resembles tricalcium phosphate considering the Ca/P ratio of 1.47 [34].…”

Section: Discussionmentioning

confidence: 99%

Dentinal tubule obliteration using toothpastes containing sodium trimetaphosphate microparticles or nanoparticles

et al. 2018

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“…Indeed, only recently was it shown , that hydrostatic environmental pressure can appreciably deform and change both a and c lattice parameters of apatite lattice dimensions. Further, it has been shown that the binding of collagen fibers and the single crystals is extremely strong, to the degree that collagen actively deforms the mineral crystals. − …”

Section: Biomimetic Potential: Learning From Whales About Large-scale...mentioning

confidence: 99%

“…It is not even clear if the bones of whales grow under ambient or high pressure conditions, and if this may have any influence on the composition, ordering, or formation of the mineral components. Indeed, only recently was it shown , that hydrostatic environmental pressure can appreciably deform and change both a and c lattice parameters of apatite lattice dimensions. Further, it has been shown that the binding of collagen fibers and the single crystals is extremely strong, to the degree that collagen actively deforms the mineral crystals. − …”

Section: Biomimetic Potential: Learning From Whales About Large-scale...mentioning

confidence: 99%

Macrobiomineralogy: Insights and Enigmas in Giant Whale Bones and Perspectives for Bioinspired Materials Science

Wysokowski

Zaslansky

Ehrlich

2020

ACS Biomater. Sci. Eng.

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The giant bones of whales (Cetacea) are the largest extant biomineral-based constructs known. The fact that such mammalian bones can grow up to 7 m long raises questions about differences and similarities to other smaller bones. Size and exposure to environmental stress are good reasons to suppose that an unexplored level of hierarchical organization may be present that is not needed in smaller bones. The existence of such a macroscopic naturally grown structure with poorly described mechanisms for biomineralization is an example of the many yet unexplored phenomena in living organisms. In this article, we describe key observations in macrobiomineralization and suggest that the large scale of biomineralization taking place in selected whale bones implies they may teach us fundamental principles of the chemistry, biology, and biomaterials science governing bone formation, from atomistic to the macrolevel. They are also associated with a very lipid rich environment on those bones. This has implications for bone development and damage sensing that has not yet been fully addressed. We propose that whale bone construction poses extreme requirements for inorganic material storage, mediated by biomacromolecules. Unlike extinct large mammals, cetaceans still live deep in large terrestrial water bodies following eons of adaptation. The nanocomposites from which the bones are made, comprising biomacromolecules and apatite nanocrystals, must therefore be well adapted to create the macroporous hierarchically structured architectures of the bones, with mechanical properties that match the loads imposed in vivo. This massive skeleton directly contributes to the survival of these largest mammals in the aquatic environments of Earth, with structural refinements being the result of 60 million years of evolution. We also believe that the concepts presented in this article highlight the beneficial uses of multidisciplinary and multiscale approaches to study the structural peculiarities of both organic and inorganic phases as well as mechanisms of biomineralization in highly specialized and evolutionarily conserved hard tissues.

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In situ compressibility of carbonated hydroxyapatite in tooth dentine measured under hydrostatic pressure by high energy X-ray diffraction

Cited by 15 publications

References 44 publications

Protein-free formation of bone-like apatite: New insights into the key role of carbonation

Protein-free formation of bone-like apatite: New insights into the key role of carbonation

Dentinal tubule obliteration using toothpastes containing sodium trimetaphosphate microparticles or nanoparticles

Macrobiomineralogy: Insights and Enigmas in Giant Whale Bones and Perspectives for Bioinspired Materials Science

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