In Situ Biomaterial Printing Technology Based on Transfer Molding

Abstract

Skin is one of the largest and most important organs in the human body. When faced with a large, full-thickness skin burn, there is not enough healthy skin to graft. In this case, we can replace our skin with biomaterials. Due to its characteristics of water permeability, antibacterial properties, biocompatibility, self-debridement, and so on, the hydrogel is undoubtedly a better alternative material. Among the methods of hydrogel preparation, in situ material molding has attracted a lot of attention for its unique advantages. Here, we proposed an in situ forming process based on transfer printing and verified the feasibility of the transfer printing process using a three-axis platform. The in situ molding equipment was designed to realize the in situ material transfer process, which prepared the conditions for the subsequent process optimization, cell experiment verification, and animal experiment.