In situ Assembly of Functionalized Single-Walled Carbon Nanotube with partially reduced Graphene oxide Nanocomposite Membrane for Chiral Separation of β-substituted-α-amino acids

Recent Advances in Separation and Analysis of Chiral Compounds

“…CNTs have also been functionalized with chiral selectors and used as substrates to achieve chiral separation. 153,164,165 Chiral CNTs were synthesized as a unique type of chiral nanomaterial, 166,167 but they were never applied for chiral membranes because of the difficulty of obtaining pure chiral CNTs.…”

“…Compared to conventional polymer membranes, carbon-based materials have exceptional atomic thickness, lamellar 2D structure, high thermal and chemical stability, antifouling property, and high tensile strength for better chiral separation performance . Most carbon materials work as the achiral supporting membrane, especially GO − and rGO, and the abundant functional groups can be modified with chiral selectors, such as CDs, chiral amino acids, peptides, and other chiral compounds. Ethylenediamine-β-CD modified GO membrane exhibited extraordinary enantioselectivity with high percent e.e.…”

“…The porous graphene with controlled and nanosized pores was immobilized on an ultrafiltration membrane for enantioselective separation of d / l -amino acids, achieving high separation factor of 4.76 for d / l -phenylalanine. CNTs have also been functionalized with chiral selectors and used as substrates to achieve chiral separation. ,, Chiral CNTs were synthesized as a unique type of chiral nanomaterial, , but they were never applied for chiral membranes because of the difficulty of obtaining pure chiral CNTs.…”

Enantioseparation Membranes: Research Status, Challenges, and Trends

“…Carbon nanotubes with high mechanical strength and large specific surface area are a kind of functional nanomaterial with excellent performance, which can significantly affect the separation process of chiral membranes. Hazarika and colleagues [77] prepared functionalized single-walled carbon nanotubes (FSWCNT) and RGO nanocomposite membranes for the separation of β-substituted-alpha-amino acids. Enantioseparation membranes containing d-tryptophan as a chiral selector preferentially adsorbed d-isomers of racemic mixtures.…”

Enantioseparation/Recognition based on nano techniques/materials

“…Optical enantiomers can be created in general by racemate resolution or asymmetrical synthesis. At the industrial and commercial level, several approaches for enantiomer separation have been developed, including chromatography [19][20][21][22][23], enzyme resolution [24], membrane separation [18,25], and chemical recognition [26,27]. These methods offer varying degrees of chiral recognition capability, but they are often time-consuming, expensive, and entail intricate separation processes.…”