In Situ and Infiltrating Ductal Carcinoma Arising in a Breast Hamartoma

Mester, Jolinda; Simmons, Rache M.; Vazquez, Madeline F.; Rosenblatt, Ruth

doi:10.2214/ajr.175.1.1750064

Cited by 34 publications

(33 citation statements)

References 6 publications

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“…Very rarely, it has also been reported that hamartomas develop into carcinoma (7). While an invasive lobular carcinoma is reported to develop in some publications, development of ductal carcinoma is the most frequently reported (15)(16)(17)(18)(19)(20)(21). Thus, once the diagnosis is established, an excision should be performed (Figure 1-3).…”

Section: Discussionmentioning

confidence: 99%

Surgical Approach to Breast Hamartoma and the Diagnostic Accuracy in Preoperative Biopsies

Tatar¹,

Erözgen²,

Tüzün³

et al. 2013

J Breasth Health

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Objective: Breast hamartomas are benign breast tumors, which are observed very rarely. We aimed to share our surgical approaches and a comparison of preoperative and postoperative pathology results of patients applying to breast polyclinics. Materials and Methods:Out of 32.000 patients approximately, we reviewed data of 12 patients with the diagnosis of breast hamartoma retrospectively, who had applied to the breast polyclinic between dates of March 2007 and October 2012.Results: All patients were female and their average age was 35 (17-58 years). Four of the hamartomas were detected in the right breast, and eight in the left breast. The average diameter of lesions was 7.3 cm (3-21cm). The diameter in our three cases was above 10 cm, and they were evaluated as giant hamartomas. All our cases underwent a fine needle aspiration biopsy (FNAB) or a core biopsy preoperatively. When the reports of preoperative biopsies performed on patients who had applied due to a palpable mass and the postoperative pathology reports were compared, it was detected that they showed a substantial correlation. Conclusion:Hamartomas are benign tumors of the breast. The rate of preoperative diagnosis is high when physical examination, imaging and histopathology approaches are taken in combination. Although very rare, a surgical excision should be performed due to the malignant change in tumors. Hamartomların dördü sağ memede sekizi sol memede saptandı. Lezyonların ortalama çapı 7,3 cm idi (min-maks; 3-21). Üç olguda lezyon çapı 10 cm üzerinde olup bu olgular dev hamartom olarak değerlendirildi. Olgularımı-zın hepsine preoperatif ince iğne aspirasyon biyopsisi (İİAB) veya kor biyopsi yapıldı. Ele gelen kitle ile başvuran hastalara yapılan preoperatif biyopsi ile postoperatif patoloji raporları karşılaştırıldığında büyük oranda korelasyon gösterdikleri tespit edildi.Sonuç: Hamartomlar memenin iyi huylu tümörleridir. Fizik muayene, gö-rüntüleme ve histopatolojinin birlikte ele alınmasıyla preoperatif tanı konma oranı yüksektir. Çok nadir de olsa malign değişim göstermesi sebebiyle cerrahi eksizyon yapılmalıdır.

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Section: Discussionmentioning

confidence: 99%

Surgical Approach to Breast Hamartoma and the Diagnostic Accuracy in Preoperative Biopsies

Tatar¹,

Erözgen²,

Tüzün³

et al. 2013

J Breasth Health

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“…For hamartoma, which is still under-recognised, the occurrence of malignancy is rare. A review of the larger series in the literature of benign hamartomas where patients' ages were reported 2-4 6 gave a mean age of 37.8 (range, 13 to 89); for the cases with malignancy, [8][9][10] including those in this report, the mean patient age was 58.2 (range, 32 to 78). The difference is significant (student's t test, p = 0.001).…”

Section: Discussionmentioning

confidence: 86%

“…9 A recent report described a case with high grade and extensive infiltrating and in situ duct carcinoma with lymph node metastases. 10 The authors report two additional cases of low grade DCIS, with one containing a focus of early invasion present entirely within the hamartoma. With the addition of these two cases to the literature, the whole spectrum of ductal and lobular carcinoma, both invasive and in situ, has now been reported.…”

Section: Discussionmentioning

confidence: 98%

“…Malignancy arising from or within a hamartoma is exceedingly rare, only four cases have been reported in the English literature, [8][9][10] including a report of two cases of infiltrating duct carcinoma, one of which was found entirely within a hamartoma. 8 Another paper reported lobular carcinoma in situ with focal invasion within a hamartoma.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ductal carcinoma in situ arising in mammary hamartoma

Tse¹,

Law²,

Pang³

et al. 2002

Journal of Clinical Pathology

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“…Should the tumour present atypical characteristics however, e.g., an increase in size or specific symptoms, excision or at least a biopsy are recommended [113,114,115]. …”

Section: Mixed Fibroepithelial Tumoursmentioning

confidence: 99%

Benign Breast Tumours - Diagnosis and Management

et al. 2018

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With improvements in breast imaging, mammography, ultrasound and minimally invasive interventions, the detection of early breast cancer, non-invasive cancers, lesions of uncertain malignant potential, and benign lesions has increased. However, with the improved diagnostic capabilities comes a substantial risk of false-positive benign lesions and vice versa false-negative malignant lesions. A statement is provided on the manifestation, imaging, and diagnostic verification of isolated benign breast tumours that have a frequent manifestation, in addition to general therapy management recommendations. Histological evaluation of benign breast tumours is the most reliable diagnostic method. According to the S3 guideline and information gained from analysis of the literature, preference is to be given to core biopsy for each type of tumour as the preferred diagnostic method. An indication for open biopsy is also to be established should the tumour increase in size in the follow-up interval, after recurring discrepancies in the vacuum biopsy results, or at the request of the patient. As an alternative, minimally invasive procedures such as therapeutic vacuum biopsy, cryoablation or high-intensity focused ultrasound are also becoming possible alternatives in definitive surgical management. The newer minimally invasive methods show an adequate degree of accuracy and hardly any restrictions in terms of post-interventional cosmetics so that current requirements of extensive breast imaging can be thoroughly met.

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In Situ and Infiltrating Ductal Carcinoma Arising in a Breast Hamartoma

Cited by 34 publications

References 6 publications

Surgical Approach to Breast Hamartoma and the Diagnostic Accuracy in Preoperative Biopsies

Surgical Approach to Breast Hamartoma and the Diagnostic Accuracy in Preoperative Biopsies

Ductal carcinoma in situ arising in mammary hamartoma

Benign Breast Tumours - Diagnosis and Management

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