In situ analysis of CCR8 + regulatory T cells and cytotoxic CD8 + T cells in human lung squamous cell carcinoma: biological insights and clinical implications
Yoshinori Hayashi,
Azumi Ueyama,
Soichiro Funaki
et al.
Abstract:Background
CCR8-expressing regulatory T cells (Tregs) are selectively localized within tumors and have gained attention as potent suppressors of anti-tumor immunity. This study focused on CCR8+ Tregs and their interaction with CD8+ T cells in the tumor microenvironment of human lung cancer. We evaluated their spatial distribution impact on CD8+ T cell effector function, specifically granzyme B (GzmB) expression, and clinical outcomes.
Methods
A total of 81 patients with lung squamous cell carcinoma (LSCC) wh… Show more
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