In silico study reveals binding potential of rotenone at multiple sites of pulmonary surfactant proteins: A matter of concern

Rajak, Prem; Roy, Sumedha; Pal, Achintya Kumar; Paramanik, Manas; Dutta, Moumita; Podder, Sayanti; Sarkar, Saurabh; Ganguly, Abhratanu; Mandi, Moutushi; Dutta, Anik; Das, Kanchana; Ghanty, Siddhartha; Khatun, Salma

doi:10.1016/j.crtox.2021.11.003

Cited by 22 publications

(12 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Molecular docking can indicate binding potential between toxicants and LS proteins. ( Li et al, 2021 , Rajak et al, 2021 ).…”

Section: Methods To Measure Lung Surfactant Functionmentioning

confidence: 99%

“…Rotenone is a broad-spectrum pesticide used globally in agriculture. Rotenone was found to interact with all LS proteins (SP-A, SP-B, SP-C, SP-D) at multiple sites via molecular docking simulations ( Rajak et al, 2021 ). Rotenone could potentially impair respiratory function and pathogen defense via the inhibition of LS proteins.…”

Section: Narrative Review Of Lung Surfactant As a Toxicological Modelmentioning

confidence: 99%

See 1 more Smart Citation

Lung surfactant as a biophysical assay for inhalation toxicology

Liu

Sayes

2023

Current Research in Toxicology

View full text Add to dashboard Cite

“…Molecular docking can indicate binding potential between toxicants and LS proteins. ( Li et al, 2021 , Rajak et al, 2021 ).…”

Section: Methods To Measure Lung Surfactant Functionmentioning

confidence: 99%

Section: Narrative Review Of Lung Surfactant As a Toxicological Modelmentioning

confidence: 99%

Lung surfactant as a biophysical assay for inhalation toxicology

Liu

Sayes

2023

Current Research in Toxicology

View full text Add to dashboard Cite

“…John et al 76 demonstrated that vitamin E has the potential to ameliorate dimethoate and malathion-induced OS in rat erythrocytes. Therefore, like other chemicals, OPs contribute to OS and subsequent pathologies that can be ameliorated to some extent by vitamin E [77][78][79][80][81][82][83][84][85][86][87] (Table 1). Eroğlu et al 62 human erythrocytes treated with 1, 10, and 100 μM concentrations of diclorvos.…”

Section: Protective Potential Of Vitamin E Against Op Induced Toxicit...mentioning

confidence: 99%

Protective Potential of Vitamin C and E against Organophosphate Toxicity: Current Status and Perspective

Rajak

Roy

Ganguly

et al. 2022

JEOH

Self Cite

View full text Add to dashboard Cite

Pesticides are an integral part of our daily life, used in agricultural fields, store rooms, residences and educational institutions to kill or repel pests. Several chemical subtypes of these compounds are available, of which organophosphate (OP) is major one. These are broad spectrum pesticides used to kill insect pests. OPs are useful but indeed they are most frequent reasons of pesticide poisoning across the globe. OP inhibits acetylcholinesterase activities that results in continuous hyper-excitable state of nicotinic and muscarinic receptors at neuromuscular junctions. Intentional or unintentional exposure to OPs causes abdominal pain, diarrhea, vomiting, muscular weakness, dementia, Central Nervous System (CNS) dysfunction and even death. Besides acetylcholinesterase inhibition, OPs are also known to trigger ROS generation within the cellular machinery which results in Oxidative Stress (OS). Free Radicals (FRs) are neutralized by antioxidant-defense system of the body. Vitamin C and vitamin E are the major exogenous antioxidants that scavenge a large amount of free radicals by donating their own electrons to FRs. This phenomenon reduces ROS and hence, OS is prevented. Therefore, vitamin C and E can be considered for daily dietary intake which might be providing prophylactic advantage against OP induced OS and pathophysiology in human beings.

show abstract

“…Simultaneously, pesticide economy has amplified by several folds worldwide to meet the ever-increasing demand of the crops, fruits, and vegetables in the global market. However, adverse effects of these formulations have been reported on non-targets ( Khatun et al, 2017 ; Dutta et al, 2017 ; Khatun et al, 2018 ; Rajak and Roy, 2018 ; Dutta et al, 2019 ; Sarkar et al, 2018 ; Rajak et al, 2021c ; Ghanty et al, 2022 ). Every year ~3.5 billion kilograms of pesticides belonging to organophosphates (OPs), organochlorines, pyrethroids, carbamates, and triazines are used in the agricultural field to enhance crop production.…”

Section: Introductionmentioning

confidence: 99%