In silico studies of the open form of human tissue transglutaminase
S. D. Ivashchenko,
D. A. Shulga,
V. D. Ivashchenko
et al.
Abstract:Human tissue transglutaminase (tTG) is an intriguing multifunctional enzyme involved in various diseases, including celiac disease and neurological disorders. Although a number of tTG inhibitors have been developed, the molecular determinants governing ligand binding remain incomplete due to the lack of high-resolution structural data in the vicinity of its active site. In this study, we obtained the complete high-resolution model of tTG by in silico methods based on available PDB structures. We discovered sig… Show more
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