Abstract:Damage-associated molecular patterns (DAMPs) are intracellular molecules released into the extracellular environment after injury. These are recognized by pattern recognition receptors (PRRs) and activate the innate immune system, triggering an inflammatory response. The most commonly studied DAMPs are S100 proteins, Thermal Shock Proteins (HSPs) and High Mobility Box Group 1 (HMGB1). Among the PRRs are the Toll-like Receptor (TLRs), the Receptor for Advanced Glycation End Products (RAGEs), Nod-like Receptor (… Show more
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