In silico screening of Moroccan medicinal plants with the ability to directly inhibit the novel coronavirus, SARS-CoV-2

Mrid, Reda Ben; Bouchmaa, Najat; Kabach, Imad; Sobeh, Mansour; Zyad, Abdelmajid; Nhiri, Mohamed; Yasri, Abdelaziz

doi:10.21203/rs.3.rs-38104/v1

Cited by 2 publications

(1 citation statement)

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“…The use of natural products and phytomedicine continues to grow fast around the world, with many people nowadays reverting to such remedies in different national healthcare settings to treat various health challenges (World Health Organization, 2004). Mrid et al (2020) investigated natural compounds in Moroccan medicinal plants that could be used as natural inhibitors of the novel coronavirus SARS-CoV-2, which causes coronavirus disease in 2019 . In their analysis, 29 Moroccan medicinal plants contained at least three of these coronavirus inhibitors.…”

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confidence: 99%

The Sultan and the Soup: A Javanese Cultural Response to COVID-19

Rahiem

Rahim

2020

J Ethn Cult Stud

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During the initial outbreak of COVID-19 in Indonesia, a poster claimed to be a suggestion from the Sultan of Yogyakarta Hamengkubuwono X (HB X), who is also the governor of the Yogyakarta Special Area (DIY), to cook and eat sayur lodeh (soup) together to help repel the plague, was circulated through WhatsApp (WA) and Social Media. The Office of Public Relations and Protocol of DIY later refuted this message. This study investigated what sayur lodeh is, what messages were contained in the poster, and how the Javanese perceived these messages within the COVID-19 context. This study used qualitative content analysis as the research method. The researchers made inferences on the meaning inside the message from HB X using cultural perspectives. The data reveals 1) Sayur lodeh is a traditional Javanese dish that includes various nutritious vegetables that are stewed in coconut milk; 2) the order to cook sayur lodeh indicates the Javanese people's high trust in the Sultan in difficult times, the hopeful and constructive attitude to the adversities, the family support, and community’s unity to resolve difficulties, and God's belief in moving forward; 3) the Javanese cooked sayur lodeh immediately, as most of them believe that it might help them escape misfortune; this assurance has been passed down from generation to generation. This study demonstrates how culture plays an important role in cultural communities, such as the Javanese, who respect and listen to cultural leaders more than other authorities. People could also obey orders against rationale or the rule of government as they have powerful cultural convictions. This study encourages the participation of cultural figures in emergency or health crisis measures, and any interventions should consider the cultural context of the population

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Section: Discussionmentioning

confidence: 99%

The Sultan and the Soup: A Javanese Cultural Response to COVID-19

Rahiem

Rahim

2020

J Ethn Cult Stud

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Implication of in silico studies in the search for novel inhibitors against SARS‐CoV‐2

Ali¹,

Alom²,

Shakya

et al. 2022

Archiv der Pharmazie

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Corona Virus Disease-19 (COVID-19) is a pandemic disease mainly caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It had spread from Wuhan, China, in late 2019 and spread over 222 countries and territories all over the world. Earlier, at the very beginning of COVID-19 infection, there were no approved medicines or vaccines for combating this disease, which adversely affected a lot of individuals worldwide. Although frequent mutation leads to the generation of more deadly variants of SARS-CoV-2, researchers have developed several highly effective vaccines that were approved for emergency use by the World Health Organization (WHO), such as mRNA-1273 by Moderna, BNT162b2 by Pfizer/BioNTech, Ad26.-COV2.S by Janssen, AZD1222 by Oxford/AstraZeneca, Covishield by the Serum Institute of India, BBIBP-CorV by Sinopharm, coronaVac by Sinovac, and Covaxin by Bharat Biotech, and the first US Food and Drug Administration-approved antiviral drug Veklury (remdesivir) for the treatment of COVID-19. Several waves of COVID-19 have already occurred worldwide, and good-quality vaccines and medicines should be available for ongoing as well as upcoming waves of the pandemic.Therefore, in silico studies have become an excellent tool for identifying possible ligands that could lead to the development of safer medicines or vaccines. Various phytoconstituents from plants and herbs with antiviral properties are studied further to obtain inhibitors of SARS-CoV-2. In silico screening of various molecular databases like PubChem, ZINC, Asinex Biol-Design Library, and so on has been performed extensively for finding effective ligands against targets. Herein, in silico studies carried out by various researchers are summarized so that one can easily find the best molecule for further in vitro and in vivo studies.

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In silico screening of Moroccan medicinal plants with the ability to directly inhibit the novel coronavirus, SARS-CoV-2

Cited by 2 publications

References 68 publications

The Sultan and the Soup: A Javanese Cultural Response to COVID-19

The Sultan and the Soup: A Javanese Cultural Response to COVID-19

Implication of in silico studies in the search for novel inhibitors against SARS‐CoV‐2

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