In Silico Screening Accelerates Nanocarrier Design for Efficient mRNA Delivery
Tristan Henser‐Brownhill,
Liam Martin,
Parisa Samangouei
et al.
Abstract:Lipidic nanocarriers are a broad class of lipid‐based vectors with proven potential for packaging and delivering emerging nucleic acid therapeutics. An important early step in the clinical development cycle is large‐scale screening of diverse formulation libraries to assess particle quality and payload delivery efficiency. Due to the size of the screening space, this process can be both costly and time‐consuming. To address this, computational models capable of predicting clinically relevant physio‐chemical pr… Show more
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