In silico radiation oncology: combining novel simulation algorithms with current visualization techniques

A four-dimensional simulation model of tumour response to radiotherapy in vivo: parametric validation considering radiosensitivity, genetic profile and fractionation

“…For the purpose of the 3D reconstruction and visualization of both the initial tumour and the simulation outcome, the 3D visualization package AVS/ Express 4.2 is used, as the block diagram of Fig. 1 depicts (for details concerning the use of AVS/ Express in the simulation model refer to Stamatakos et al, 2002).…”

“…There is a difference from the previous versions of the model Stamatakos et al, 2001aStamatakos et al, , 2002 in which all time registers were set to zero at the beginning of the simulation procedure. In the present, more biologically accurate version the time register of a given class within a GC is randomly set to a certain value between 0 and the maximum duration of the corresponding cell cycle phase.…”

An advanced discrete state–discrete event multiscale simulation model of the response of a solid tumor to chemotherapy: Mimicking a clinical study

“…cell necrosis following a prolonged residence of a tumor cell in the G0 phase etc.) (Duechting and Vogelsaenger, 1981;Ginsberg et al, 1993;Stamatakos et al, 2002Stamatakos et al, , 2006aStamatakos et al, , 2006bStamatakos et al, , 2007Dionysiou et al, 2004, Dionysiou and Stamatakos, 2006Deisboeck et al, 2009). State transitions can be decided by making use of several possible "decision calculators" such as cytokinetic diagrams, agent-based techniques etc.…”

“…Hybrid models with a strong discrete character have been shown to be particularly adequate for the simulation of the response of large imageable clinical tumors to therapeutic interventions such as radiotherapy and chemotherapy (Stamatakos et al, 2002(Stamatakos et al, , 2006a(Stamatakos et al, , 2006bDionysiou et al, 2004Dionysiou et al, , 2006. Since clinical validation is a sine qua non necessity for clinically oriented multiscale cancer models, this paper Carcinoma of the breast is the most commonly diagnosed cancer in women.…”

Simulation-based optimization of radiotherapy: Agent-based modeling and reinforcement learning

“…Cancer has become the second cause of death worldwide after cardiovascular disease, even in developed countries [37], and yet there is no absolute cure for it. The main methods of treating cancer are surgery, chemotherapy and radiotherapy.…”