In Silico, Preparation and in Vitro Studies of Benzylidene-Based Hydroxy Benzyl Urea Derivatives as Free Radical Scavengers in Parkinson’s Disease
JAGDISH CHAND,
AMARJITH THIYYAR KANDY,
KAVERI PRASAD
et al.
Abstract:Objective: The study focuses on the benzylidene-based hydroxy benzyl urea derivative as free radical scavengers in PD.
Methods: The derivatives were designed, synthesized, and characterized using FTIR, 1H, 13C-NMR, and Mass spectrometry. Further in vitro studies were performed on the SHSY-5Y cell lines. Molecular docking and molecular dynamic studies were performed at 100 ns to predict the binding affinity and stability of the ligand/protein complex.
Results: Among the nine derivatives, compounds HBU-2, and HB… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.