In Silico Prediction and In Vitro Assessment of Multifunctional Properties of Postbiotics Obtained From Two Probiotic Bacteria

Aguilar-Toalá, José E.; Hall, Felicia; Urbizo-Reyes, Uriel; Garcı́a, Hugo S.; Vallejo-Córdoba, Belinda; González‐Córdova, Aarón F.; Hérnández-Mendoza, Adrian; Liceaga, Andrea M.

doi:10.1007/s12602-019-09568-z

Cited by 38 publications

(14 citation statements)

References 57 publications

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“…However, a microbial strain or consortium does not have to qual ify as a probiotic (while living) for the inactivated ver sion to be accepted as a postbiotic. Specific strains of Akkermansia muciniphila, Faecalibacterium prausnitzii, Bacteroides xylanisolvens, Bacteroides uniformis, Eubacterium hallii, Clostridium cluster IV and XIVa, Apilactobacillus kunkeei and the fungus Saccharomyces boulardii have all been investigated for potential ben eficial effects in an inanimate form and would fit the definition of postbiotic should a health benefit be demonstrated [26][27][28][29][30] . Many bacterial lysates have been used for medical purposes, but there is a clear need for more robust clinical trials.…”

Section: Proposed Definition Of Postbioticmentioning

confidence: 99%

The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics

Salminen

Collado

Endo

et al. 2021

Nat Rev Gastroenterol Hepatol

985

616

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In 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened a panel of experts specializing in nutrition, microbial physiology, gastroenterology, paediatrics, food science and microbiology to review the definition and scope of postbiotics. The term ‘postbiotics’ is increasingly found in the scientific literature and on commercial products, yet is inconsistently used and lacks a clear definition. The purpose of this panel was to consider the scientific, commercial and regulatory parameters encompassing this emerging term, propose a useful definition and thereby establish a foundation for future developments. The panel defined a postbiotic as a “preparation of inanimate microorganisms and/or their components that confers a health benefit on the host”. Effective postbiotics must contain inactivated microbial cells or cell components, with or without metabolites, that contribute to observed health benefits. The panel also discussed existing evidence of health-promoting effects of postbiotics, potential mechanisms of action, levels of evidence required to meet the stated definition, safety and implications for stakeholders. The panel determined that a definition of postbiotics is useful so that scientists, clinical triallists, industry, regulators and consumers have common ground for future activity in this area. A generally accepted definition will hopefully lead to regulatory clarity and promote innovation and the development of new postbiotic products.

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Section: Proposed Definition Of Postbioticmentioning

confidence: 99%

The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics

Salminen

Collado

Endo

et al. 2021

Nat Rev Gastroenterol Hepatol

985

616

View full text Add to dashboard Cite

show abstract

“…In vitro tests demonstrated that the IC and CW fractions showed inhibitory activities of the angiotensin converting enzyme (>90%), chelating agents (>79%) and antioxidants. The results based on in silico and in vitro analyzes suggest that L. casei CRL 431 and B. coagulans GBI-30 strains appear to be promising sources of postbiotics and may confer health benefits through their multifunctional properties [ 200 ].…”

Section: Prebiotics Probiotics Paraprobiotics Postbiotics and Synbiotics: Challenges And Controversiesmentioning

confidence: 99%

Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges

Ailioaie

Litscher

2021

IJMS

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In recent decades, researchers around the world have been studying intensively how micro-organisms that are present inside living organisms could affect the main processes of life, namely health and pathological conditions of mind or body. They discovered a relationship between the whole microbial colonization and the initiation and development of different medical disorders. Besides already known probiotics, novel products such as postbiotics and paraprobiotics have been developed in recent years to create new non-viable micro-organisms or bacterial-free extracts, which can provide benefits to the host with additional bioactivity to probiotics, but without the risk of side effects. The best alternatives in the use of probiotics and postbiotics to maintain the health of the intestinal microbiota and to prevent the attachment of pathogens to children and adults are highlighted and discussed as controversies and challenges. Updated knowledge of the molecular and cellular mechanisms involved in the balance between microbiota and immune system for the introspection on the gut–lung–brain axis could reveal the latest benefits and perspectives of applied photobiomics for health. Multiple interconditioning between photobiomodulation (PBM), probiotics, and the human microbiota, their effects on the human body, and their implications for the management of viral infectious diseases is essential. Coupled complex PBM and probiotic interventions can control the microbiome, improve the activity of the immune system, and save the lives of people with immune imbalances. There is an urgent need to seek and develop innovative treatments to successfully interact with the microbiota and the human immune system in the coronavirus crisis. In the near future, photobiomics and metabolomics should be applied innovatively in the SARS-CoV-2 crisis (to study and design new therapies for COVID-19 immediately), to discover how bacteria can help us through adequate energy biostimulation to combat this pandemic, so that we can find the key to the hidden code of communication between RNA viruses, bacteria, and our body.

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“…Such microbial products may include primary metabolites (e.g., lactate, acetate, propionate), bacteriocins, reuterin, or other secreted molecules (e.g., immunomodulatory secreted peptides; [43]), which can be defined as "postbiotics" [44]. The actual contribution of these molecules to the interaction of probiotic formulations on host health is not known but, in light of data obtained from in vitro experiments, cannot be excluded [45][46][47].…”

Section: Extracellular Microbial Products In Probiotic Formulationsmentioning

confidence: 99%

The Neglected Microbial Components of Commercial Probiotic Formulations

2020

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Producers of probiotic products are legally required to indicate on the label only the minimum numbers of viable microorganisms at the end of shelf life expressed as colony-forming units (CFUs). Label specifications, however, describe only a fraction of the actual microbiological content of a probiotic formulation. This paper describes the microbiological components of a probiotic product that are not mentioned on the label, such as the actual number of CFUs, the presence of viable cells that cannot generate colonies on agar plates, and the abundance of dead cells. These “hidden” microbial fractions in probiotic products, the abundance of which may change during the shelf life, can promote biological responses in the host. Therefore, they should not be ignored because they may influence the efficacy and can be relevant for immunocompromised or fragile consumers. In conclusion, we propose the minimum requirements for microbiological characterization of probiotic products to be adopted for label specifications and clinical studies.

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In Silico Prediction and In Vitro Assessment of Multifunctional Properties of Postbiotics Obtained From Two Probiotic Bacteria

Cited by 38 publications

References 57 publications

The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics

The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics

Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges

The Neglected Microbial Components of Commercial Probiotic Formulations

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