In silico modelling and NMR Characterization of some steroids from Strychnos innocua (Delile) root bark as potential antifungal agents

Uttu, Ahmed Jibrin; Sallau, M. S.; Ibrahim, H.; Iyun, Ogunkemi Risikat Agbeke

doi:10.1016/j.steroids.2023.109222

Cited by 1 publication

(2 citation statements)

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“…0.10 mL of the test microorganisms, was seeded onto the sterilized media and evenly distributed throughout its surface using a sterile swap. Each inoculation medium had a well cut out of its center using a standard cork borer with a 6 mm diameter (Uttu et al, 2023).…”

Section: Culture Media Preparationsmentioning

confidence: 99%

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Antibacterial and Antifungal Activities of Some Hydrazones Synthesized From Nicotinic Acid Hydrazide

Muhammad,

Ibrahim,

Ayo

et al. 2024

FJS

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N’-(2-pyridinylmethylene)nicotinohydrazide A, N’-(4-pyridinylmethylene)nicotinohydrazide B, N’-(2- ethoxybenzylidene)nicotinohydrazide C, N’-(4- ethoxybenzyldene)nicotinohydrazide D and N’-(2-hydroxyl-5-methoxybenzylidene)nicotinohydrazide E, was prepared by refluxing the ethanolic solution of nictonic acid hydrazide and ethanolic solutions of 2-pyridinrcarboxaldehyde, 4-pyridinecarboxaldehyde, 2-ethoxybenzaldehyde, 4-ethoxybenzaldehyde and 2-hydroxy-5-methoxybenzaldehyde in 1:1 mole ratio for 4 hours in a separate reactions. The compounds obtained had a melting point between (120-236 oC) and a percentage yield between (52.38-77.70 %). They were crystalline solids. The compounds' solubility were assessed in water, ethanol, methanol, acetone, hexane, diethyl ether, dimethyl sulfoxide (DMSO), ethyl acetate, and chloroform. The substances were discovered to be fully soluble in DMSO and methanol. FT-IR, 1H-NMR and 13C-NMR were used for the characterization of the compounds. The antibacterial and antifungal properties were tested against Methicillin-resistant Staphylococcus Aureus, Vancomycin-resistant Enterococci, S. aureus, S. typhi, P. aeruginosa, A. nigre, A. flavus, and C. albicans. The zones of inhibitions ranged from 22 to 28 mm and the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) were found to be 0.063 mg/mL, 0.125 mg/mL and 0.125 mg/mL respectively. These indicated that the compounds might be good potential drug candidates.

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Section: Culture Media Preparationsmentioning

confidence: 99%

“…The compounds were prepared as two-fold serial dilutions at concentrations of 0.500 mg/mL, 0.250 mg/mL, 0.125 mg/mL, 0.063 mg/mL, and 0.031 mg/mL for the MIC determination. The contents were also utilized for the determination of the minimum bactericidal and fungicidal concentrations, as described by Uttu et al, (2023).…”

Section: Culture Media Preparationsmentioning

confidence: 99%