In silico modeling the potential clinical effect of growth factor treatment on the metabolism of human nucleus pulposus cells
Emily E. McDonnell,
Tara Ní Néill,
Niamh Wilson
et al.
Abstract:BackgroundWhile growth factors have the potential to halt degeneration and decrease inflammation in animal models, the literature investigating the effect of dosage on human cells is lacking. Moreover, despite the completion of clinical trials using growth differentiation factor‐5 (GDF‐5), no results have been publicly released.AimsThe overall objective was to quantitatively assess the effect of three clinically relevant concentrations of GDF‐5 (0.25, 1, and 2 mg) as a therapeutic for disc regeneration.Materia… Show more
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