In silico model of infection of a CD4(+) T-cell by a human immunodeficiency type 1 virus, and a mini-review on its molecular pathophysiology

Abstract

In silico model of infection of a CD4(+) T-cell by a human immunodeficiency type 1 virus, and a mini-review on its molecular pathophysiology.Vivanco-Lira, A.

The HIV-1 Gag Protein Displays Extensive Functional and Structural Roles in Virus Replication and Infectivity

“…Moreover, complex stability is further maintained through electrostatic interactions with the base amino acids in the zinc finger linker and the disordered NTD of NC [ 89 ]. Mutations affecting the ordered zinc finger folding and the formation of the hydrophobic plateau [ 85 ] modify the structure of the virion core, alter Gag trafficking [ 82 ] and result in the loss of viral infectivity [ 90 ]. For example, the substitution of P408 for D408 in the basic linker resulted in non-infectious, immature virions [ 91 ].…”