2020
DOI: 10.21203/rs.3.rs-130707/v1
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In Silico Metabolic Modeling Reveals Potential Muscle Metabolite Markers of Insulin Resistance in Newly Diagnosed Diabetic Patients

Abstract: Background Type 2 diabetes mellitus (T2DM) is a challenging and globally ubiquitous metabolic disease caused by insulin resistance. Skeletal muscle is the major insulin-sensitive tissue that plays a great role in blood sugar homeostasis. Dysfunction of muscle metabolism is implicated in the disturbance of glucose hemostasis and the development of insulin resistance and T2DM. Here, we attempted to find metabolic dysregulations that are associated with the onset of T2DM. Besides, metabolite markers of T2DM were … Show more

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“…The earlier versions of this manuscript are reposited as a preprint in Research Square with DOI 10.21203/rs.3.rs-130707/v1 and 10.21203/rs.3. rs-124888/v1 [55,56].…”
Section: Acknowledgmentsmentioning
confidence: 99%
“…The earlier versions of this manuscript are reposited as a preprint in Research Square with DOI 10.21203/rs.3.rs-130707/v1 and 10.21203/rs.3. rs-124888/v1 [55,56].…”
Section: Acknowledgmentsmentioning
confidence: 99%