In silico investigations of intratumoral heterogeneous interstitial fluid pressure

Waldeland, Jahn Otto; Gaustad, Jon-Vidar; Rofstad, Einar K.; Evje, Steinar

doi:10.1016/j.jtbi.2021.110787

Cited by 4 publications

(1 citation statement)

References 71 publications

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“…In tumor tissues where the vascular regulation imbalance exists [ 4 , 5 ], the related cytokines Angiogenin-2 (ANG-2) and vascular endothelial growth factor (VEGF) are overexpressed to promote the pathological angiogenesis particularly in the early period of the tumor progression, which are immature and leaky blood vessels [ 6 , 7 ]. It is found that abnormal tumor blood vessels lead to high interstitial pressure [ 8 , 9 ] and poor blood perfusion in tumor tissues [ 10 ]. The deficiency in the vessel structures and functions is a major factor that impedes the delivery of thermo/chemo-therapeutic materials [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Remodeling of tumor microenvironment for enhanced tumor chemodynamic/photothermal/chemo-therapy

et al. 2022

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The anticancer treatment is largely affected by the microenvironment of the tumors, which not only resists the tumors to the thermo/chemo-therapy, but also promotes their growth and invasion. In this work, the angiogenesis factor is balanced by combining with the breathing hyperoxygen, for regulating the tumor microenvironment and also for relieving hypoxia and high tissue interstitial pressure, which promote drug delivery to tumor tissues by increasing the in vivo perfusion and reversing the immunosuppressive tumor. In addition, the designed multifunctional nanoparticles have a great potential for applications to the tumor dual-mode imaging including magnetic resonance (MR) and photoacoustic (PA) imaging. This work proposes a promising strategy to enhance the thermo/chemo-therapy efficacy by remodeling the tumor microenvironment, which would provide an alternative to prolong the lifetime of tumor patients. Graphical Abstract

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