In silico identification and synthesis of a multi-drug loaded MOF for treating tuberculosis

Exploring the antimicrobial potential of isoniazid loaded Cu-based metal–organic frameworks as a novel strategy for effective killing of Mycobacterium tuberculosis

“…55,56 In 2019, Simon et al 57 performed isoniazid drug delivery using MIL-100(Fe) MOFs for the first time. Similarly, Gaweł et al 58 and Acharya et al 59 performed the isoniazid drug delivery using Fe-MIL-101-NH 2 and BIO-MOF-100 but did not determine the antibacterial activity of the released isoniazid. A study by demonstrates the application of mixed ligand Cu-MOFs (MOFs-2) as a drug delivery vehicle for the release of an anthracycline antibiotic, Doxorubicin hydrochloride (DOX).…”