In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene
Md. Mostafa Kamal,
Md. Sohel Mia,
Md. Omar Faruque
et al.
Abstract:Single nucleotide polymorphisms (SNPs) are one of the most common determinants and potential biomarkers of human disease pathogenesis. SNPs could alter amino acid residues, leading to the loss of structural and functional integrity of the encoded protein. In humans, members of the minichromosome maintenance (MCM) family play a vital role in cell proliferation and have a significant impact on tumorigenesis. Among the MCM members, the molecular mechanism of how missense SNPs of minichromosome maintenance complex… Show more
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