2012
DOI: 10.1007/s12539-012-0138-5
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In silico exploration of novel phytoligands against probable drug target of Clostridium tetani

Abstract: Though tetanus is an old disease with well known medicines, its complications are still a serious issue worldwide. Tetanus is mainly due to a powerful neurotoxin, tetanolysin-O, produced by a Gram positive anaerobic bacterium, Clostridium tetani. The toxin has a thiol-activated cytolysin which causes lysis of human platelets, lysosomes and a variety of subcellular membranes. The existing therapy seems to have challenged as available vaccines are not so effective and the bacteria developed resistance to many dr… Show more

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Cited by 4 publications
(6 citation statements)
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“…V. cholerae also showed drug resistance to Trimethoprim. S. aureus showed multidrug resistance to present generation drugs such as Methicillin and Vancomycin (Skariyachan et al, 2012). Our previous results clearly indicate that these bacteria became resistant to conventionally used drugs and emerged as superbugs (multidrug-resistant organisms).…”
Section: Resultsmentioning
confidence: 85%
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“…V. cholerae also showed drug resistance to Trimethoprim. S. aureus showed multidrug resistance to present generation drugs such as Methicillin and Vancomycin (Skariyachan et al, 2012). Our previous results clearly indicate that these bacteria became resistant to conventionally used drugs and emerged as superbugs (multidrug-resistant organisms).…”
Section: Resultsmentioning
confidence: 85%
“…Hence, in the present study, we have focused to inhibit the virulent functions of the drug-resistant genes by novel phytoligands. Our previous studies proved the utility of computer-aided virtual screening toward many multidrug-resistant pathogens (Skariyachan et al, 2012). Several herbal substances are known to have vital inhibitory properties against various drug targets of many gastrointestinal pathogens (Eumkeb & Chukrathok 2013;Eumkeb, Siriwong, & Thumanu, 2012;Rúa et al, 2012;Schrader, 2010).…”
Section: Resultsmentioning
confidence: 94%
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“…A transsynaptic transport of the intact toxin may lead to its dissemination into the CNS, but the toxin cannot pass the blood--brain barrier [13]. The role of tetanolysin is not fully known, but it may lead to cell lysis, thereby promoting local tissue damage and bacterial growth [14].…”
Section: The Toxinsmentioning
confidence: 99%
“…The methodology behind building homology models is outside the scope of this review, but here we remark on the popularity of the approach in practice. It is notable that a number of recent successful virtual screening projects used homology models of the protein receptor, and for some the best template for homology modeling was fairly divergent from the target structure, in terms of percent sequence identity [126,127,128,129,130,131,132].…”
Section: Challenges In Protein-ligand Dockingmentioning
confidence: 99%