In silico drug repurposing of anticancer drug 5-FU and analogues against SARS-CoV-2 main protease: molecular docking, pharmacokinetics and chemical reactivity
Abstract:Since the last COVID-19 outbreak, several approaches have been put forward to quickly tackle this global calamity. One of the strategies employed by a handful of researchers is the so-called drug repurposing, which consists in finding new therapeutic uses for approved drugs. Following the same paradigm, we report in the present study an investigation of the potential inhibitory activity of 5-FU and nineteen of its analogues against the SARS-CoV-2 main protease in the framework of molecular docking. This work a… Show more
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