In Silico designed cell-penetrating anti-cancer peptide specifically inhibits VEGF-A expression
Nilanjan Banerjee,
Laboni Roy,
Suman Panda
et al.
Abstract:Vascular Endothelial Growth Factor A (VEGF A), a pluripotent cytokine and angiogenic growth factor mediates the switch to an angiogenic phenotype in cancer cells. The interaction of VEGF A protein with the VEGF receptors (VEGFR 1and VEGFR 2) starts downstream effect that promotes angiogenesis by mediating migration and increasing the permeability of endothelial cells. A cis regulatory elements consisting of a polypurine polypyrimidine tract in the proximal 36-bp region, can participate in the formation of a st… Show more
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