In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases

Abstract

Abstract-Throughout the years, the palliative treatment of bone metastases using bone seeking radiotracers has been part of the therapeutic resources used in oncology. However, the choice of which bone seeking agent to use is not consensual. Computer simulation is a simple and practical solution to study and to compare a variety of radioisotopes. This study aimed to compare 11 different radioisotopes currently in use or under research. Hence, computational models were used to estimate the percentage of deoxyribonucleic acid damage, the probability of correct DNA repair, and the radiation-induced cellular effects post-irradiation.