In Silico Characterization of a Cyclin Dependent Kinase -A (CDKA) and its Coding Gene in some Oryza Species

Fouad, Ahmed S.; AlSobeai, Sanad M.

doi:10.21123/bsj.2020.17.3.0760

Cited by 2 publications

(2 citation statements)

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“…Regarding morphological changes, the senescence cell has an irregular shape and increased lysosomal content (39)(40)(41). A study carried out in mice revealed that mice exposed to stress can activate pathway of p53/p21 and p16INK4a and p21 that are involved in senescence (42,43). Another study showed that injection of mice with endocrine mediators can activate pathway of p53/ p21that is involved in senescence (44).…”

Section: Cellular Senescence Mediates the Aging Processmentioning

confidence: 99%

Effect of DNA damage mediating psychosocial stress on aging

Al-Maeni,

Shaymaa Fouad Rasheed Al Khazraji

2023

Iraqi j. cancer med. genet.

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Adversity and psychosocial stress are involved in aging through the following pathways. psychological stress enhances the nerve system to secrete endocrine mediators (hormones). Mitochondrial respiration mediates energy production stimulated by binding to these hormones to their receptors. Energy produced by mitochondria accelerates metabolism and, in its turn, leads to increases in reactive oxygen species (ROS) of free radicals. Cellular stress and accumulation of damage can result from an excess of ROS. Accumulation of damage comprises damages in telomeric and nontelomeric DNA, in addition to mitochondrial DNA. Mitochondrial DNA damage plays an important role in increasing the pathway of p53/p21. The expression of the PGC-1α gene is inhibited by activation of the previous pathway that generates a decrease in mitochondrial biogenesis. The low level of mitochondrial biogenesis generates mitophagy defects and increases the level of dysfunctional mitochondria that lead to a high level of ROS production. Nuclear DNA damage and mitochondrial dysfunction stimulate necrosis or cell senescence. Necrotic cells enhance the inflammatory activity by which damage-associated molecular patterns (DAMPs) are continuously secreted. Senescent cells secrete high levels of the senescence-associated secretory phenotype (SASP) that includes tumor necrosis factor TNF-α and interleukin-6 (IL-6) as inflammatory cytokines, and MCP-2 and interleukin-8 (IL-8) as chemokines. All these processes work together to accelerate the biological aging process by causing defects related to aging such as diabetes and cardiovascular disease.

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Section: Cellular Senescence Mediates the Aging Processmentioning

confidence: 99%

Effect of DNA damage mediating psychosocial stress on aging

Al-Maeni,

Shaymaa Fouad Rasheed Al Khazraji

2023

Iraqi j. cancer med. genet.

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“…The in silico analyses were recruited to identify several important genes in Oryza species including genes encoding enzymes controlling shikimate pathway (13), salt stress responsive genes (14), regulatory elements for pathogenesis-related proteins (15), nucleotide binding site-leucine-rich repeats playing an important role in the plant defense (16) and Cyclin dependent kinase B (CDKB) gene (17).…”

Section: Introductionmentioning

confidence: 99%

Molecular Modeling and in Silico Characterization of a Pathogenesis-Related Protein-10 (PR10) and its Coding Genes in some Oryza Species

Fouad

Hafez

2020

Baghdad Sci.J

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Rice is a major staple food for more than two thirds of the world population. Pathogenesis-related proteins-10 (PR10) have a range of 154 to 163 amino acid with molecular weight ~ 17 kDa. They are acidic and generally intracellular and cytosolic proteins accumulate in plants in response to biotic and abiotic stresses. In the present study, a PR10 gene and its corresponding protein were characterized in O. sativa, O. barthii, O. glaberrima, O. glumipatula, O. meridionalis, O. nivara, O. rufipogon and O. punctata. The results revealed a narrow range of variation at both DNA and protein levels in all examined species except O. glumipatula. The latter showed a relatively obvious structural variation at protein level. Such variation may be beneficial against different types of stress that requires further elucidation to exploit in rice breeding programs.

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In Silico Characterization of a Cyclin Dependent Kinase -A (CDKA) and its Coding Gene in some Oryza Species

Cited by 2 publications

References 46 publications

Effect of DNA damage mediating psychosocial stress on aging

Effect of DNA damage mediating psychosocial stress on aging

Molecular Modeling and in Silico Characterization of a Pathogenesis-Related Protein-10 (PR10) and its Coding Genes in some Oryza Species

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