In silico binding affinity to cyclooxygenase-II and green synthesis of benzylpyrazolyl coumarin derivatives

Saha, Arijit; Payra, Soumen; Verma, Sant Kumar; Mandal, Mou; Thareja, Suresh; Banerjee, Subhash

doi:10.1039/c5ra16643h

Cited by 39 publications

(10 citation statements)

References 32 publications

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“…Thus, [C 4 MIM][BF 4 ]–water mixtures allowed effective dispersion of hydrophobic C 60 fullerenes, which showed high biomedical potential . Benzylpyrazolyl coumarin scaffolds, which presumably possessed inhibitory activity toward the cyclooxygenase COX-II, were synthesized by using [C 5 MIM][Br] as catalyst and reaction media . The enzyme phytase self-assembled into active nanospheres in [C 4 MIM][BF 4 ], and these nanospheres were subsequently used for production of platinum-decorated, curcumin-loaded phytase nanospeheres, which the authors considered “multifunctional protein-based drug delivery vehicles” …”

Section: Chemical Applications Of Ionic Liquids In Pharmacymentioning

confidence: 99%

Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine

2017

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Ionic liquids are remarkable chemical compounds, which find applications in many areas of modern science. Because of their highly tunable nature and exceptional properties, ionic liquids have become essential players in the fields of synthesis and catalysis, extraction, electrochemistry, analytics, biotechnology, etc. Apart from physical and chemical features of ionic liquids, their high biological activity has been attracting significant attention from biochemists, ecologists, and medical scientists. This Review is dedicated to biological activities of ionic liquids, with a special emphasis on their potential employment in pharmaceutics and medicine. The accumulated data on the biological activity of ionic liquids, including their antimicrobial and cytotoxic properties, are discussed in view of possible applications in drug synthesis and drug delivery systems. Dedicated attention is given to a novel active pharmaceutical ingredient-ionic liquid (API-IL) concept, which suggests using traditional drugs in the form of ionic liquid species. The main aim of this Review is to attract a broad audience of chemical, biological, and medical scientists to study advantages of ionic liquid pharmaceutics. Overall, the discussed data highlight the importance of the research direction defined as "Ioliomics", studies of ions in liquids in modern chemistry, biology, and medicine.

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Section: Chemical Applications Of Ionic Liquids In Pharmacymentioning

confidence: 99%

Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine

2017

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“…The more amino acid residues that interact with the ligands, the smaller the value of ΔG will be (negative) and the reaction will take place spontaneously and bind very strongly so that the inhibitory effect it creates will also be stronger [13] .…”

Section: Resultsmentioning

confidence: 99%

In Silico Study : Phyllanthus Niruri L as Immunomodulator Against Covid-19

2020

IJFMT

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In December 2019, a mysterious case of pneumonia was first reported in Wuhan, Hubei Province. The source of transmission of this case is still unknown, but the first case was linked to the fish market in Wuhan. From 18 December to 29 December 2019, there were five patients treated with Acute Respiratory Distress Syndrome (ARDS). 2 From 31 December 2019 to 3 January 2020 this case increased rapidly, marked by 44 cases reported. In less than a month, the disease has spread to other provinces in China, Thailand, Japan and South Korea. This virus can be transmitted from human to human and has spread widely in China and more than 190 other countries and territories. On 12 March 2020, WHO announced COVID-19 as a pandemic. As of March 29, 2020, there were 634,835 cases and 33,106 deaths worldwide. While in Indonesia, 1,528 cases were confirmed with COVID-19 and 136 deaths. Phyllanthus niruri L (meniran) is one type of immunostimulator that can improve the immune system in animal experiments and humans. This study aims to determine Phyllanthus niruri L as an immunomodulator for Covid-19. From the results of research conducted that Phyllanthus niruri L can improve the activities and functions of several non-specific immune system components and specific immune systems, both soluble and cell-related forms. The conclusion from the results of this study is Phyllanthus niruri L as an immunomodulator for Covid-19.

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“…The use of ionic liquid makes this approach environmentally and ecofriendly benign (Scheme 11b). [59] Another alternative approach for the synthesis of a vast array of pyrazolyl-coumarin derivatives 49 has been established by Jadhav and Shloorkar in the same year (Scheme 11c). [60] By using 10 mol% of alum [KAl(SO 4 ) 2 • 12H 2 O] as the transitionmetal-free catalyst, the desired products 49 derived from the multicomponent reaction of 4-hydroxycoumarin 1, aldehydes 31, hydrazines 47, and ethyl acetoacetate 48 under microwave irradiation, has been obtained in 70-97% yield.…”

Section: Synthesis Of Pyrazolones/pyrazoles Linked or Fused With 4-hydroxycoumarinmentioning

confidence: 99%

4‐Hydroxycoumarin: A Versatile Substrate for Transition‐metal‐free Multicomponent Synthesis of Bioactive Heterocycles

2021

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One-pot multi-component reactions especially under transition-metal-free catalysis served as an efficient, and environmentally friendly method for the construction of value-added compounds. Their importance in organic synthesis has drastically increased due to their operational simplicity, cost-effectiveness, step-and pot-economic nature. On the other hand, the molecular hybridization concept has recently emerged as a key fascinating area in medicinal and organic chemistry for the design of new drugs. Owing to the widespread occurrence in natural products, and pharmaceutical agents, the incorporation of another heterocycle either as substituents or as a fused material into 4-hydroxycoumarin moiety offers new opportunities for the broad application of the targeted coumarin-heterocycles into many branches of chemistry. Considering the importance of both the topics, here we have reviewed the developments achieved in the synthesis of diverse medicinally privileged oxygen, and nitrogen-containing heterocycles as well as spiro-heterocycles either linked or fused with coumarin moiety by using readily accessible 4-hydroxycoumarin as the starting material via one-pot multi-component reaction under transition-metalfree conditions.[a] B. Borah, K.

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In silico binding affinity to cyclooxygenase-II and green synthesis of benzylpyrazolyl coumarin derivatives

Abstract: Here, we have reported enhanced molecular binding affinities of benzylpyrazolyl coumarin scaffolds with COX-II inhibitor and an ionic liquid catalyzed simple green synthetic route to access these scaffolds.

Cited by 39 publications

References 32 publications

Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine

Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine

In Silico Study : Phyllanthus Niruri L as Immunomodulator Against Covid-19

4‐Hydroxycoumarin: A Versatile Substrate for Transition‐metal‐free Multicomponent Synthesis of Bioactive Heterocycles

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