In silico assessment of the dosimetric quality of a novel, automated radiation treatment planning strategy for linac-based radiosurgery of multiple brain metastases and a comparison with robotic methods

The purpose of this work was to compare dose distributions between two radiosurgery modalities, single‐isocenter volumetric modulated arc therapy (VMAT), and GammaKnife Perfexion (GK), in the treatment of a large number (≥7) of brain metastases. Twelve patients with 103 brain metastases were analyzed. The median number of targets per patient was 8 (range: 7–14). GK plans were compared to noncoplanar VMAT plans using both 6‐MV flattening filter‐free (FFF) and 10‐MV FFF modes. Parameters analyzed included radiation therapy oncology group conformity index (CI), 12, 6, and 3 Gy isodose volumes (V12 Gy, V6 Gy, V3 Gy), mean and maximum hippocampal dose, and maximum skin dose. There were statistically significant differences in CI (2.5 ± 1.6 vs 1.6 ± 0.8 and 1.7 ± 0.9, P < 0.001, P < 0.001), V12 Gy (2.8 ± 6.1 cc vs 3.0 ± 5.2 cc and 3.1 ± 5.4 cc, P = 0.003, P < 0.001), and V3 Gy (323.0 ± 294.8 cc vs, 880.1 ± 369.1 cc and 937.9 ± vs 361.9 cc, P = 0.005, P = 0.001) between GK versus both 6‐MV FFF and 10‐MV FFF. No significant differences existed for maximum hippocampal or skin doses. In conclusion, highly optimized VMAT produced improved conformity at the expense of a higher V12 Gy and V3 Gy volume when compared with highly optimized GK.

Section: Discussionmentioning

confidence: 99%

GammaKnife versus VMAT radiosurgery plan quality for many brain metastases

Potrebko

Keller

All

et al. 2018

“…These structures were used for collimator angle optimization. Arc geometry (four arc fields; one full coplanar arc with a 0° couch and three half noncoplanar arc fields a 315°, 45°, and 90° or 270° couch) arranged with a single isocenter automatically located on the basis of the distance between each lesion . The prescription dose was the same as that of the clinical treatment plan for 95% volume of the PTV all , and 6‐MV flattening filter‐free photon beams were used.…”

Section: Methodsmentioning

confidence: 99%

Dosimetric effect of rotational setup errors in stereotactic radiosurgery with HyperArc for single and multiple brain metastases

Sagawa

Ohira

Ueda

et al. 2019

PurposeIn stereotactic radiosurgery (SRS) with single‐isocentric treatments for brain metastases, rotational setup errors may cause considerable dosimetric effects. We assessed the dosimetric effects on HyperArc plans for single and multiple metastases.MethodsFor 29 patients (1–8 brain metastases), HyperArc plans with a prescription dose of 20–24 Gy for a dose that covers 95% (D95%) of the planning target volume (PTV) were retrospectively generated (Ref‐plan). Subsequently, the computed tomography (CT) used for the Ref‐plan and cone‐beam CT acquired during treatments (Rot‐CT) were registered. The HyperArc plans involving rotational setup errors (Rot‐plan) were generated by re‐calculating doses based on the Rot‐CT. The dosimetric parameters between the two plans were compared.ResultsThe dosimetric parameters [D99%, D95%, D1%, homogeneity index, and conformity index (CI)] for the single‐metastasis cases were comparable (P > 0.05), whereas the D95% for each PTV of the Rot‐plan decreased 10.8% on average, and the CI of the Rot‐plan was also significantly lower than that of the Ref‐plan (Ref‐plan vs Rot‐plan, 0.93 ± 0.02 vs 0.75 ± 0.14, P < 0.01) for the multiple‐metastases cases. In addition, for the multiple‐metastases cases, the Rot‐plan resulted in significantly higher V10Gy (P = 0.01), V12Gy (P = 0.02), V14Gy (P = 0.02), and V16Gy (P < 0.01) than those in the Ref‐plan.ConclusionThe rotational setup errors for multiple brain metastases cases caused non‐negligible underdosage for PTV and significant increases of V10Gy to V16Gy in SRS with HyperArc.

“…Fig. 7 compares the PCI of this study with the historical data from other institutes and modalities such as LINAC circular and mMLC, 18 Cyberknife, 19 Gamma Knife, and RapidArc. 20 The V12, PCI, and mGI have been reported as key indicators for brain toxicities, 1-3 such as radionecrosis, etc.…”

Section: Discussionmentioning

confidence: 99%

Strategies to optimize stereotactic radiosurgery plans for brain tumors with volumetric‐modulated arc therapy

Wang

DeNittis

2020

Purpose Prescription practice in SRS plans for brain tumors differs significantly for different modalities. In this retrospective study, the strategies to optimize SRS plans for brain tumors with volumetric arc therapy (VMAT) were presented. Methods Fifty clinically treated cases were stratified by the maximum target size into two groups (≥ 2 cm in 25 cases and <2 cm but ≥1 cm in 25 cases), which were optimized using traditional LINAC MLC‐based approaches with the average prescription isodose line (P‐IDL) of (91.4 ± 0.6)%. Four to five plans have been created for each case with variation of the P‐IDL from 65% to 90%. The optimization strategies to select an optimal P‐IDL, to use tuning structures within the target and beyond as well as to use NTO (normal tissue objectives), were applied to all new plans. Results The optimal P‐IDL was found to be around 75%. After applying the new optimization strategies with an average P‐IDL of 74.8%, the mean modified gradient index (mGI) and V12 were reduced by 25% and 35%, respectively for both groups. The Paddick conformity index (PCI) was averagely improved by 8%. The average homogeneity index (HI) and focal index (FI) were increased by 22% and 50%, respectively. The mGI was inversely proportional to the PTV volumes. The shape of the dose distribution in target was also changed from concave to convex. The comparison of PCI with historical data from other institutes and modalities shows that the plans in this study have the best conformity near the target. Conclusions With the new optimization strategies for VMAT SRS plan of brain tumor more conformal plans in both high and intermediate dose region (~50% of the PD) were created, in which the dose in the core of the target was notably increased while V12 and mGI were significantly decreased, and PCI was improved. The mGI was inversely proportional to the PTV volumes. The optimal P‐IDL is around 75%. The average PCI is the best in this study compared with the published historical data. These strategies are applicable to treatment planning for multiple brain and liver tumors where sparing the tissue peripheral to the target is critical.