In-silico and In-vivo Long-term Safety Studies of Mangosteen Rind Ethanol Extract (Garcinia mangostana Linn.)
Abstract:Mangosteen rind has been used extensively to treat a variety of diseases. However, research on the use of mangosteen, especially over the long-term, remains limited. The aim of this study was to evaluate the toxicity of ethanol extract of mangosteen rind (EEMR) to ensure its safety. The in silico method used the Protox-II web server to test the safety of marker compounds found in EEMR (xanthones, alpha-mangostin and gamma-mangostin). The in vivo method involved the oral feeding of EEMR to rats at doses of 100,… Show more
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