In silico and in vitro approaches to evaluate the bioactivities of Chaetomorpha linum

Gayathiri, Ekambaram; Mahalakshmi, Periyasamy; Thangaraj, Pradeep; Prakash, Palanisamy; Selvam, Kuppusamy; Manivasagaperumal, R.; Ragunathan, Manikkavalli Gurunathan; Jayanthi, J.; Kumaravel, Priya

doi:10.1016/j.sajb.2022.06.067

Cited by 3 publications

(4 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CL is recognized as a macroalga with high abundance and has the potential to be utilized in daily life [ 31 , 32 ]. Many studies have reported the bioactive potential of CL as a supplement or feed ingredient [ 10 , 20 , 32 ]. The use of marine products as supplements in animal feed provides an opportunity to increase animal growth performance because most marine products, such as microalgae and macroalgae, have suitable nutrient profiles [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…Gayathiri et al . [ 20 ] reported that CL is an important source of natural antioxidants with abundant secondary metabolic activity. CL polysaccharides also have promising potential as antidiabetic agents [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…This species is characterized by filamentous, unbranched, and stiff thallus with bright green to dark green color [19], living in colonies. Gayathiri et al [20] reported that CL is an important source of natural antioxidants with abundant secondary metabolic activity. CL polysaccharides also have promising potential as antidiabetic agents [21].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dietary macroalgae Chaetomorpha linum supplementation improves morphology of small intestine and pectoral muscle, growth performance, and meat quality of broilers

Saragih,

Fauziah,

Saputri

et al. 2024

Vet World

View full text Add to dashboard Cite

Background and Aim: Over the last decades, the poultry industry has experienced steady growth. Although the industry is gradually expanding in Indonesia, poultry feed production has always been expensive. There is a need to study alternative ingredients to obtain affordable feed from natural resources. Chaetomorpha linum (CL) is an abundant macroalgae available throughout the year in Indonesia. This study aimed to determine the effect of CL on the histological structure of the small intestine, pectoralis muscle, growth performance, and meat quality of broilers. Materials and Methods: This study used 300-day-old chick (DOC) male broilers that were reared until they were 21 days old. This study used a completely randomized design with four treatment groups and five replications, and each replication group contained 15 DOC individuals. The treatment groups consisted of Control (CON), CON basal feed (BF), CL1 (0.75%/kg BF), CL2 (1.5%/kg BF), and CL3 (3%/kg BF) groups. The histological structure of the small intestine, pectoralis muscle, growth performance, and meat quality of the broiler was examined. Results: Small intestine and pectoral muscle histomorphology, growth performance, and meat quality were significantly improved in the CL2 (1.5%) and CL3 (3%) groups compared with the CL1 (0.75%) and CON groups. Conclusion: Dietary CL supplementation ameliorates small intestine and pectoral muscle histomorphology, growth performance, and meat quality of broilers. Keywords: Chaetomorpha linum, growth performance, pectoral muscle, small intestine, water-holding capacity.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary macroalgae Chaetomorpha linum supplementation improves morphology of small intestine and pectoral muscle, growth performance, and meat quality of broilers

Saragih,

Fauziah,

Saputri

et al. 2024

Vet World

View full text Add to dashboard Cite

show abstract

“…By unveiling the phytochemical diversity within this plant, this study not only contributes to the scientific understanding of its chemical composition but also highlights its potential as a valuable resource in the development of pharmaceuticals and therapeutics. [16,17] Experiments in anti-bacterial assays could shed light on the selectivity of the phytochemicals action on specific bacteria. In turn, docking the investigated chemical structures to the targets could shed light on the molecular mechanism of their activity.…”

Section: Discussionmentioning

confidence: 99%

Exploring Phytochemicals and Anti-bacterial Properties of Bougainvillea glabra: A Systematic Review with an in silico Perspective

PM Ravikumar,

Thangaraj

2023

Pharmacogn. Res.

View full text Add to dashboard Cite

Background: Anti-microbial resistance is a major global hazard to human health, which is exacerbated by high costs and low returns associated with bringing new antibiotics to market. Plants have a diverse array of bioactive secondary metabolites, representing an exciting new option for drug discovery. Materials and Methods: We used a systemic review of the phytochemical composition of Bougainvillaea glabra flower extracts and computational analysis of its antibacterial activity. SwissADME and STRING are used to identify effective medications like phytochemicals and their targets. Results: Totally 36 bioactive compounds were identified in B. glabra among the 467 investigations. We used SwissADME to test these compounds for possible drug-like properties and to find their specific target. The N-(1-Deoxy-1-fructosyl) phenylalanine was virtual docked with a bacterial target protein, tryptophanyl-tRNA synthetase. We examined binding affinity and interactions in these models to estimate their anti-bacterial potential. The in silico study found solid evidence for specific phytochemicals anti-microbial activities. Notably, quercetin had a binding affinity of -7.83 and was crucial in inhibiting the translational process of protein synthesis. Conclusion: This computational investigation gives information on the potential anti-bacterial properties of phytochemicals produced from B. glabra. Our findings not only call for additional testing but also point to the possibility of synthesising novel anti-bacterial drugs derived from nature. This study helps the ongoing battle against antibiotic resistance by clearing the path for the development of novel therapeutic alternatives to combat bacterial infections through the use of computational approaches.

show abstract

Ethical principles and scientific advancements: In vitro, in silico, and non-vertebrate animal approaches for a green ecotoxicology

Pastorino,

Prearo,

Barceló

2024

Green Analytical Chemistry

View full text Add to dashboard Cite

In silico and in vitro approaches to evaluate the bioactivities of Chaetomorpha linum

Cited by 3 publications

References 42 publications

Dietary macroalgae Chaetomorpha linum supplementation improves morphology of small intestine and pectoral muscle, growth performance, and meat quality of broilers

Dietary macroalgae Chaetomorpha linum supplementation improves morphology of small intestine and pectoral muscle, growth performance, and meat quality of broilers

Exploring Phytochemicals and Anti-bacterial Properties of Bougainvillea glabra: A Systematic Review with an in silico Perspective

Ethical principles and scientific advancements: In vitro, in silico, and non-vertebrate animal approaches for a green ecotoxicology

Contact Info

Product

Resources

About