In Silico Analysis of Tumor Necrosis Factor α-Induced Protein 8-Like-1 (TIPE1) Protein

Shen, Pei; Zhang, Hong; Su, Zhaoliang; Wang, Shengjun; Xu, Huaxi

doi:10.1371/journal.pone.0134114

Cited by 11 publications

(6 citation statements)

References 23 publications

(32 reference statements)

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“…As a negative regulator of immunity and inflammation, TIPE2 expression levels are downregulated in most types of cancer tissues compared with those in adjacent normal tissues ( 5 , 20 – 23 ). However, a previous study has reported higher levels of TIPE2 protein in tissues from patients with CRC compared with those in healthy human colon tissues collected by colonoscopy ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, high expression levels of TIPE1 are detected in most human carcinoma cell lines, including cervical and ovarian cancer cell lines ( 5 , 19 ). Different posttranslational modifications of TIPE1 have also been predicted to exist ( 12 , 20 ). TIPE1 has two transcript variants, both of which encode the same protein ( , accessed on 23 December 2019).…”

Section: Introductionmentioning

confidence: 99%

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Expression of TIPE family members in human colorectal cancer

et al. 2020

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The tumor necrosis factor α-induced protein 8 (TNFAIP8)-like (TIPE) protein family comprises four members, namely TNFAIP8, TIPE1, TIPE2 and TIPE3, which are involved in multiple processes in cancer. The current study aimed to investigate the expression patterns and potential clinical roles of the TIPE family members in human colorectal cancer (CRC). Paired tumor and adjacent tissue samples were collected from 49 patients with CRC, and the relative mRNA expression levels of the TIPE family members in these samples were evaluated by using reverse transcription-quantitative PCR, and the protein levels in five randomly selected pairs of tumor and adjacent tissue samples were detected by western blot analysis. The mRNA expression levels of the TIPE family members were significantly downregulated in CRC tumor tissues compared with those in the adjacent tissues; however, within each sample, TNFAIP8 and TIPE3 protein levels were only partially consistent with their mRNA levels. In addition, the mRNA expression levels between each pair of TIPE family members exhibited a positive linear relationship, and TIPE2 mRNA levels exhibited strong linear associations with those of TNFAIP8 and TIPE1. TNFAIP8 mRNA expression levels in tumor tissues were significantly associated with the tumor differentiation grade, and TIPE2 mRNA expression levels in tumor tissues were significantly associated with sex. TIPE1 and TIPE3 mRNA expression levels in tumor tissues exhibited no associations with patient clinicopathological characteristics. In addition, the mRNA expression patterns of the TIPE family members were analyzed using data from The Cancer Genome Atlas data set, and the results also demonstrated that TNFAIP8, TIPE2 and TIPE3 mRNA levels were downregulated in patients with colon adenocarcinoma compared with those in normal controls. These results provided evidence that the four members of the TIPE family may affect each other to mediate the carcinogenesis of CRC, and that TIPE2 may serve an important role in CRC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Expression of TIPE family members in human colorectal cancer

et al. 2020

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“…In a Parkinson’s disease model, TIPE1 binds to FBXW5, increasing autophagy through activation of TSC2 [ 20 ]. Due to the three-dimensional structure of TIPE1 protein, TIPE1 was predicted to interact with FBXW5, caspase8 and so on [ 21 ]. In our study, we found TIEP1 arrest NSCLC cancer cell cycle, inhibited apoptosis and metastasis (Figures 3 – 5 ).…”

Section: Discussionmentioning

confidence: 99%

TIPE1 function as a prognosis predictor and negative regulator of lung cancer

et al. 2017

Oncotarget

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TIPE1 (tumor necrosis factor-α-induced protein 8-like 1 or TNFAIP8L1) belongs to the TIPE (TNFAIP8) family, which act as a regulator of cell death. However, the expression and biologic functions of TIPE1 in lung cancer are largely unknown. Here, we investigated the roles of TIPE1 in lung cancer. Evaluated by qRT-PCR and immunohistochemical staining, lower TIPE1 mRNA and protein expression was found in the lung tumor tissue, compared with adjacent non-tumor tissues, which positively correlated with tumor patient survival. Overexpression of TIPE1 by lentivirus system in TIPE1-downregulated lung cancer cells significantly diminished cell growth and colony formation, companied with proliferation inhibition, apoptosis induction and invasion inhibition. It was identified to be due to TIPE1-regulated Cyclin D1, Cyclin B1, caspase 8, Caspase3, MM2 and MMP9 expression. Consistently, using a homograft tumor model in Balb/c mice, we discovered that TIPE1 prevented the growth and tumor weight of murine lung cancer homografts. Our findings revealed the anti-tumor role of TIPE1 in lung cancer cells and TIPE1 might be a novel prognostic indicator for lung cancer patients.

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“…This family is comprised of four members, namely, TIPE or TNFAIP8 (tumor necrosis factor-α-induced protein 8), TIPE1 (TNFAIP8-like 1, or TNFAIP8L1), TIPE2 (TNFAIP8-like 2 or TNFAIP8L2), and TIPE3 (TNFAIP8-like 3 or TNFAIP8L3) [ 1 ]. Despite the fact that all the four proteins of this family share a significant sequence homology (~54% sequence identity), they are involved in the regulation of different cellular activities [ 2 , 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Further, TIPE1 was speculated to be associated with cardiac decompensation linked with diabetes and to interact with FBXW5 and caspase-8. Besides, different post-translational modifications were also predicted to exist in the case of TIPE1 [ 2 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

TIPE Family of Proteins and Its Implications in Different Chronic Diseases

Bordoloi

Banik

Shabnam

et al. 2018

IJMS

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The tumor necrosis factor-α-induced protein 8-like (TIPE/TNFAIP8) family is a recently identified family of proteins that is strongly associated with the regulation of immunity and tumorigenesis. This family is comprised of four members, namely, tumor necrosis factor-α-induced protein 8 (TIPE/TNFAIP8), tumor necrosis factor-α-induced protein 8-like 1 (TIPE1/TNFAIP8L1), tumor necrosis factor-α-induced protein 8-like 2 (TIPE2/TNFAIP8L2), and tumor necrosis factor-α-induced protein 8-like 3 (TIPE3/TNFAIP8L3). Although the proteins of this family were initially described as regulators of tumorigenesis, inflammation, and cell death, they are also found to be involved in the regulation of autophagy and the transfer of lipid secondary messengers, besides contributing to immune function and homeostasis. Interestingly, despite the existence of a significant sequence homology among the four members of this family, they are involved in different biological activities and also exhibit remarkable variability of expression. Furthermore, this family of proteins is highly deregulated in different human cancers and various chronic diseases. This review summarizes the vivid role of the TIPE family of proteins and its association with various signaling cascades in diverse chronic diseases.

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In Silico Analysis of Tumor Necrosis Factor α-Induced Protein 8-Like-1 (TIPE1) Protein

Cited by 11 publications

References 23 publications

Expression of TIPE family members in human colorectal cancer

Expression of TIPE family members in human colorectal cancer

TIPE1 function as a prognosis predictor and negative regulator of lung cancer

TIPE Family of Proteins and Its Implications in Different Chronic Diseases

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