In-silico Analysis of the Role of Boundary Conditions in the Induced Drift of 2D Spiral Waves

Scroll wave with negative filament tension in a model of the left ventricle of the human heart and its overdrive pacing

“…Furthermore, besides a spontaneous breakup, there are several LVC-hindering factors such as the domain dimension (a certain pacing period may be effective in two dimensions but ineffective in three dimensions [28]), an insufficient electrode size or pacing current [20], anisotropy [16], and a small difference between the minimum 1D assimilable pacing period and the spiral wave period [15]. The 2D results for the isotropic and anisotropic square domains [10,11,32] had the same effective pacing periods, which shows that the domain dimension, anisotropy degree, wall thickness gradient, and heart shape did not affect the interval in the parameter ranges examined in our studies.…”

“…In our previous papers, we studied this process, which we will refer to as low-voltage cardioversion (LVC), in two-dimensional (2D) models of the myocardium. We considered a simple two-variable Aliev-Panfilov model [9] in the isotropic medium [10,11], an anisotropic medium with straight fibers and mechanoelectrical feedback [12], a Luo-Rudy I model [13,14], and a ten Tusscher-Panfilov model, TP06 [15]. However, the LVC has been studied in 3D anatomical models of the heart only for the positive filament tension [16].…”