In silico analysis of the cyanobacterial lectin scytovirin: new insights into binding properties

Siqueira, Andrei Santos; Lima, Alex Ranieri Jerônimo; Souza, Rafael Conceição de; Santos, Alberdan Silva; Júnior, João Lídio da Silva Gonçalves Vianez; Gonçalves, Evonnildo Costa

doi:10.1007/s11033-017-4116-1

Cited by 7 publications

(6 citation statements)

References 22 publications

(33 reference statements)

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“…SVN binds to the Manα(1-2), Manα(1-6),Manα(1-6)Man tetrasaccharides of the viral enveloped glycoproteins, especially to gp120, but also gp160 and less effectively to gp41 [ 43 ]. The binding proceeds simultaneously at the two domains (SD1 and SD2), but domain SD1 has a higher affinity for oligosaccharides than SD2 [ 75 , 76 ]. The in silico studies showed that for the two domains the mechanism of the SVN–Man4 interactions was different [ 76 ].…”

Section: Cyanobacterial Lectinsmentioning

confidence: 99%

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Antiviral Cyanometabolites—A Review

et al. 2021

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Global processes, such as climate change, frequent and distant travelling and population growth, increase the risk of viral infection spread. Unfortunately, the number of effective and accessible medicines for the prevention and treatment of these infections is limited. Therefore, in recent years, efforts have been intensified to develop new antiviral medicines or vaccines. In this review article, the structure and activity of the most promising antiviral cyanobacterial products are presented. The antiviral cyanometabolites are mainly active against the human immunodeficiency virus (HIV) and other enveloped viruses such as herpes simplex virus (HSV), Ebola or the influenza viruses. The majority of the metabolites are classified as lectins, monomeric or dimeric proteins with unique amino acid sequences. They all show activity at the nanomolar range but differ in carbohydrate specificity and recognize a different epitope on high mannose oligosaccharides. The cyanobacterial lectins include cyanovirin-N (CV-N), scytovirin (SVN), microvirin (MVN), Microcystisviridis lectin (MVL), and Oscillatoria agardhii agglutinin (OAA). Cyanobacterial polysaccharides, peptides, and other metabolites also have potential to be used as antiviral drugs. The sulfated polysaccharide, calcium spirulan (CA-SP), inhibited infection by enveloped viruses, stimulated the immune system’s response, and showed antitumor activity. Microginins, the linear peptides, inhibit angiotensin-converting enzyme (ACE), therefore, their use in the treatment of COVID-19 patients with injury of the ACE2 expressing organs is considered. In addition, many cyanobacterial extracts were revealed to have antiviral activities, but the active agents have not been identified. This fact provides a good basis for further studies on the therapeutic potential of these microorganisms.

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Section: Cyanobacterial Lectinsmentioning

confidence: 99%

“…The binding proceeds simultaneously at the two domains (SD1 and SD2), but domain SD1 has a higher affinity for oligosaccharides than SD2 [ 75 , 76 ]. The in silico studies showed that for the two domains the mechanism of the SVN–Man4 interactions was different [ 76 ].…”

Section: Cyanobacterial Lectinsmentioning

confidence: 99%

Antiviral Cyanometabolites—A Review

et al. 2021

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“…It increases insulin sensitivity thanks to the antioxidant effects of phycobiliproteins. So, interleukin 6 (IL-6), which inhibits insulin signaling molecules such as insulin receptor substrate, is regularized [ 141 , 142 , 143 ], and the activity of the lipoprotein lipase, an important enzyme in the lipid metabolism when it is altered in HIV patients, is increased [ 144 , 145 ].…”

Section: An Overview Of the Antiviral Effects Of A Supplementary Microalgae Diet And Its Possible Action On Sars-cov-2mentioning

confidence: 99%

Evaluation of Microalgae Antiviral Activity and Their Bioactive Compounds

et al. 2021

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During the last year, science has been focusing on the research of antivirally active compounds overall after the SARS-CoV-2 pandemic, which caused a great amount of deaths and the downfall of the economy in 2020. Photosynthetic organisms such as microalgae are known to be a reservoir of bioactive secondary metabolites; this feature, coupled with the possibility of achieving very high biomass levels without excessive energetic expenses, make microalgae worthy of attention in the search for new molecules with antiviral effects. In this work, the antiviral effects of microalgae against some common human or animal viruses were considered, focusing our attention on some possible effects against SARS-CoV-2. We summed up the data from the literature on microalgae antiviral compounds, from the most common ones, such as lectins, polysaccharides and photosynthetic pigments, to the less known ones, such as unidentified proteins. We have discussed the effects of a microalgae-based genetic engineering approach against some viral diseases. We have illustrated the potential antiviral benefits of a diet enriched in microalgae.

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“…The search for these new resources largely involves the biotechnology and bioprospecting of microorganisms that are not toxic to the environment in which they live and that present advantages in their production. The researches commonly involve interest for metabolites with biological activity and, for a high-potential of biomass which are produced by these microorganisms, making them an alternative raw material to existing ones [ 1 , 3 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…In the search for inputs, it is well known that the marine environment is abundant in organisms that produce substances with high biotechnological value; enable a wide variety of products and which can be used as possible solutions to diseases due to the discovery of new substances with biological activity. Therefore, there is a great demand for different species of marine cyanobacteria and microalgae which may have unknown substances or untapped actions with pharmacological potential [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Advances in the Biotechnological Potential of Brazilian Marine Microalgae and Cyanobacteria

Oliveira

Costa

et al. 2020

Molecules

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Due the worldwide need to improve care for the environment and people, there is a great demand for the development of new renewable, sustainable, and less polluting technologies for food, health, and environmental industries. The marine environment is one of the main areas investigated in the search for alternatives to the raw materials currently used. Thereby, cyanobacteria and marine microalgae are microorganisms that are capable of producing a diverse range of metabolites useful for their cellular maintenance, but that also represent a great biotechnological potential. Due its great potential, they have an enormous appeal in the scientific research where, the biological activity of metabolites produced by these microorganisms, such as the antioxidant action of sterols are, some examples of biotechnological applications investigated around the world. Thereby, Brazil due to its extensive biodiversity, has high potential as a raw material supplier of marine waters, researching cyanobacteria and microalgae metabolites and their applications. Thus, this rapid review intends to present some important contributions and advances from Brazilian researchers, using the biomass of Brazilian cyanobacteria and marine microalgae, in order to illustrate the value of what has already been discovered and the enormous potential of what remains unexplored so far.

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In silico analysis of the cyanobacterial lectin scytovirin: new insights into binding properties

Cited by 7 publications

References 22 publications

Antiviral Cyanometabolites—A Review

Antiviral Cyanometabolites—A Review

Evaluation of Microalgae Antiviral Activity and Their Bioactive Compounds

Advances in the Biotechnological Potential of Brazilian Marine Microalgae and Cyanobacteria

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