In silico analysis of the effect of vasicine and vasinone against human tyrosinase receptor in the management of hyperpigmentation of skin diseases

Sharmila, C; Devi, R. Chithra; Sureka, A.; Muthukumar, N.; Banumathi, V.

doi:10.31024/ajpp.2019.5.3.13

Cited by 4 publications

(3 citation statements)

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“…That extract was recommended for further research as a bioactive preparation and a suitable candidate for the treatment of systemic candidiasis-associated skin lesions. Secondary metabolites commonly found and characterized in other species of the genus Sida L.—such as apigenin with clinical effects on skin aging [ 12 , 13 ], and vasicin and vasinone blocking tyrosinases causing hyperpigmented skin diseases [ 14 ]—have not yet been analyzed and tested in S. hermaphrodita . Only information about extraction of rutin, isoquercitrin, quercimeritrin, herbacetin, coumarin, scopoletin, and scopolin in the aboveground part of the S. hermaphrodita were reported a long time ago [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Establishment of Stem Cell-like Cells of Sida hermaphrodita (L.) Rusby from Explants Containing Cambial Meristems

Kaňuková

Gubišová

Klčová

et al. 2022

IJMS

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The in vitro cultures of plant stem cells and stem cell-like cells can be established from tissues containing meristematic cells. Chemical compounds—as well as their production potential—is among the emerging topics of plant biotechnology. We induced the callus cell biomass growth and characterized the parameters indicating the presence of stem cells or stem cell-like cells. Four types of explants (stem, petiole, leaf, root) from Sida hermaphrodita (L.) Rusby and various combinations of auxins and cytokinins were tested for initiation of callus, growth of sub-cultivated callus biomass, and establishment of stem cells or stem cell-like cells. Induction of callus and its growth parameters were significantly affected both by the explant type and the combination of used plant growth hormones and regulators. The responsibility for callus initiation and growth was the highest in stem-derived explants containing cambial meristematic cells. Growth parameters of callus biomass and specific characteristics of vacuoles confirmed the presence of stem cells or stem cell-like cells in sub-cultivated callus cell biomass. Establishment of in vitro stem cell or stem cell-like cell cultures in S. hermaphrodita can lead to the development of various applications of in vitro cultivation systems as well as alternative applications of this crop.

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Section: Introductionmentioning

confidence: 99%

Establishment of Stem Cell-like Cells of Sida hermaphrodita (L.) Rusby from Explants Containing Cambial Meristems

Kaňuková

Gubišová

Klčová

et al. 2022

IJMS

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“…These proteins have garnered significant attention in medical research and therapeutic development due to their potential to address a broad spectrum of inflammatory conditions, including autoimmune diseases, chronic inflammation, and inflammatory responses linked to infections or tissue damage. The major psoriasis inflammatory markers includes IL-23 [4], IL-17 [5], IL-6 [6], TNF-α [4], NLRP-3 [7], and 12R Lipoxygenase [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Molecular Interaction Analysis of Phytochemicals as the Prospective Potential Multi-Target Inhibitors Related to Psoriasis and Other Autoimmune Disorders

Swain,

Maddi

2024

JDDMC

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Psoriasis is an inflammatory skin disease in which the immune system's T cells are activated and trigger inflammation within the skin. Inflammatory markers, such as IL-23, IL-17, IL-6, TNF-α, NLRP-3, and 12R Lipoxygenase (12 R-Lox), play a crucial role in the inflammatory pathway. Anti-inflammatory drugs are used to modulate the immune response and reduce excessive inflammation that contributes to disease progression. However, many existing anti-inflammatory drugs often target a single marker, potentially limiting their effectiveness and leading to side effects. Emerging research has highlighted the potential of various phytochemicals to modulate inflammatory processes and contribute to improved health outcomes. This study aimed to explore the potential of phytochemicals as alternative therapeutic agents targeting multiple psoriasis inflammatory biomarkers. In silico molecular docking was conducted on various phytochemicals, including curcumin, mangiferin, reservatrol, silybin, quercertin, piperine, and naringin against different inflammatory biomarkers: IL-6, IL-17, IL-23, TNF-α, NLRP-3 and 12R-Lox. The results illustrated that among the phytochemicals, silybin exhibited the highest docking score and inhibiting effects on all the inflammatory biomarkers. Curcumin, mangiferin, silybin and piperine demonstrated binding with multiple inflammatory biomarkers. Additionally, 12R-Lox displayed the highest binding affinity with all the phytochemicals. The inhibition and binding effects of the remaining phytochemicals under evaluation were moderate. The combination of these phytochemicals can be used for the preparation of medications targeting psoriasis.

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“…In silico methods are good scientific tools for understanding biological processes [41]. Using molecular docking tools has become an important step in developing and discovering new drugs for many diseases, as it saves a lot of effort, time, and money as well [42][43][44].…”

Section: Introductionmentioning

confidence: 99%

In Silico and In Vitro Anticoagulant Activity Detection of Quercetin, Rutin, and Troxerutin as New Potential Inhibitors of Factor Xa

2022

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Factor Xa is an important target for the development of new anticoagulants. The present study aims to examine the effect of three compounds (Quercetin and its derivatives Rutin and Troxerutin) in comparison with Rivaroxaban on activated Human Clotting factor X (PDB ID: 2w26). Molecular docking was performed using iGemDock v2.1 software to predict their antiactivating factor X activity and Autodock vina software to check the bonds formed. Next, the in vitro biological effects on both PT and aPTT coagulation time were studied. Troxerutin and Rutin showed the best interaction values with 2w26 enzyme, and the binding energy was [(-185.743 kcal/mol) and (-178.034 kcal/mol)], respectively, using iGemDock; While the binding energy of Rivaroxaban was (-149.661 kcal/mol). The results of the in vitro study showed that the studied compounds have an effect in prolonging PT, aPTT compared to both negative and positive control. However, Troxerutin gave the highest prolongation of the evaluated clotting times, consistent with the in silico study the results..

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In silico analysis of the effect of vasicine and vasinone against human tyrosinase receptor in the management of hyperpigmentation of skin diseases

Cited by 4 publications

References 0 publications

Establishment of Stem Cell-like Cells of Sida hermaphrodita (L.) Rusby from Explants Containing Cambial Meristems

Establishment of Stem Cell-like Cells of Sida hermaphrodita (L.) Rusby from Explants Containing Cambial Meristems

Molecular Interaction Analysis of Phytochemicals as the Prospective Potential Multi-Target Inhibitors Related to Psoriasis and Other Autoimmune Disorders

In Silico and In Vitro Anticoagulant Activity Detection of Quercetin, Rutin, and Troxerutin as New Potential Inhibitors of Factor Xa

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