“…Our modelling determined that PRR and vesicle networks converge at the level of HspB1 and HSG, which seem to link the exposure to S. aureus with the ubiquitination process (Katz et al., 2002; Parcellier et al., 2003). On this note, we have recently found that profilaggrin undergoes ubiquitin‐proteasome system (UPS)‐mediated turnover, with relevance to the disease, especially with the context of FLG mutations, which alter predicted stability of this protein (Paul et al., 2023). Given the enrichment in the ubiquitination marks, it is hence plausible that ubiquitination could mediate profilaggrin/filaggrin trafficking to the endocytic system (Ageta & Tsuchida, 2019) and sorting into exosomes at the level of MVBs, beyond its role in proteasomal degradation (Liao et al., 2022); it could also participate in gene regulation by promoting nuclear localisation (Liao et al., 2022).…”