In silico agent-based modeling approach to characterize multiple in vitro tuberculosis infection models
Alexa Petrucciani,
Alexis Hoerter,
Leigh Kotze
et al.
Abstract:In vitro models of Mycobacterium tuberculosis (Mtb) infection are a valuable tool for examining host-pathogen interactions and screening drugs. With the development of more complex in vitro models, there is a need for tools to help analyze and integrate data from these models. To this end, we introduce an agent-based model (ABM) representation of the interactions between immune cells and bacteria in an in vitro setting. This in silico model was used to simulate both traditional and spheroid cell culture models… Show more
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